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An animal study on the effectiveness of platelet-rich plasma as a direct pulp capping agent – Scientific Reports


  • Frencken, J. E. et al. Minimal intervention dentistry for managing dental caries—a review: Report of a FDI task group. Int. Dent. J. 62, 223–243. https://doi.org/10.1111/idj.12007 (2012).

    Article 
    PubMed 

    Google Scholar
     

  • Nie, E. et al. Effectiveness of direct pulp capping bioactive materials in dentin regeneration: A systematic review. Mater. Basel https://doi.org/10.3390/ma14226811 (2021).

    Article 

    Google Scholar
     

  • Sun, H. H., Jin, T., Yu, Q. & Chen, F. M. Biological approaches toward dental pulp regeneration by tissue engineering. J. Tissue Eng. Regen Med. 5, e1-16. https://doi.org/10.1002/term.369 (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hanna, S. N., Alfayate, R. P. & Prichard, J. Vital pulp therapy an insight over the available literature and future expectations. Eur. Endod. J. 5(1), 46. https://doi.org/10.14744/eej.2019.44154 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Islam, R. et al. Direct pulp capping procedures—evidence and practice. Jpn. Dent. Sci. Rev. 59, 48–61. https://doi.org/10.1016/j.jdsr.2023.02.002 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Okamoto, M. et al. Novel evaluation method of dentin repair by direct pulp capping using high-resolution micro-computed tomography. Clin. Oral. Investig. 22, 2879–2887. https://doi.org/10.1007/s00784-018-2374-5 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Orhan, E. O., Maden, M. & Senguuven, B. Odontoblast-like cell numbers and reparative dentine thickness after direct pulp capping with platelet-rich plasma and enamel matrix derivative: A histomorphometric evaluation. Int. Endod. J. 45, 317–325. https://doi.org/10.1111/j.1365-2591.2011.01977.x (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Asgary, S., Parirokh, M., Eghbal, M. J. & Ghoddusi, J. SEM evaluation of pulp reaction to different pulp capping materials in dog’s teeth. Iran Endod. J. 1, 117–123 (2006).

    PubMed 

    Google Scholar
     

  • Kassis, C. et al. Response of dental pulp capped with calcium-silicate based material, calcium hydroxide and adhesive resin in rabbit teeth. Braz. J. Oral Sci. 21, e223816 (2022).

    Article 

    Google Scholar
     

  • Makarla, S. et al. Determining the best anti-microbial properties of dental cements used for pulp capping procedures using deep dentinal carious material. J. Oral Maxillofac. Pathol. 27, 239. https://doi.org/10.4103/jomfp.jomfp_109_21 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Song, M. et al. Clinical and molecular perspectives of reparative dentin formation: Lessons learned from pulp-capping materials and the emerging roles of calcium. Dent. Clin. North Am. 61, 93–110. https://doi.org/10.1016/j.cden.2016.08.008 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • da Rosa, W. L. O. et al. Current trends and future perspectives of dental pulp capping materials: A systematic review. J. Biomed. Mater. Res. B Appl. Biomater. 106, 1358–1368. https://doi.org/10.1002/jbm.b.33934 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Islam, R. et al. Histological evaluation of a novel phosphorylated pullulan-based pulp capping material: An in vivo study on rat molars. Int. Endod. J. 54, 1902–1914. https://doi.org/10.1111/iej.13587 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Pisanti, S. & Sciaky, I. Origin of calcium in the repair wall after pulp exposure in the dog. J. Dent Res. 43, 641–644. https://doi.org/10.1177/00220345640430050401 (1964).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lipski, M. et al. Factors affecting the outcomes of direct pulp capping using Biodentine. Clin. Oral. Investig. 22, 2021–2029. https://doi.org/10.1007/s00784-017-2296-7 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Tawil, P. Z., Duggan, D. J. & Galicia, J. C. Mineral trioxide aggregate (MTA): its history, composition, and clinical applications. Compend. Contin. Educ. Dent. 36(4), 15488578 (2015).


    Google Scholar
     

  • Marques, M. S., Wesselink, P. R. & Shemesh, H. Outcome of direct pulp capping with mineral trioxide aggregate: A prospective study. J. Endod. 41, 1026–1031. https://doi.org/10.1016/j.joen.2015.02.024 (2015).

    Article 
    PubMed 

    Google Scholar
     

  • Nair, P. N., Duncan, H. F., Pitt Ford, T. R. & Luder, H. U. Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: a randomized controlled trial. Int. Endod. J. 41(2), 128–150. https://doi.org/10.1111/j.1365-2591.2007.01329.x (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tomson, P. L. et al. Dissolution of bio-active dentine matrix components by mineral trioxide aggregate. J. Dent. 35, 636–642. https://doi.org/10.1016/j.jdent.2007.04.008 (2007).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Parirokh, M. & Torabinejad, M. Mineral trioxide aggregate: a comprehensive literature review–Part III: Clinical applications, drawbacks, and mechanism of action. J Endod 36, 400–413. https://doi.org/10.1016/j.joen.2009.09.009 (2010).

    Article 
    PubMed 

    Google Scholar
     

  • Management of deep caries and the exposed pulp. European society of endodontology developed, b. et al. European society of Endodontology position statement. Int. Endod. J. 52, 923–934. https://doi.org/10.1111/iej.13080 (2019).

    Article 

    Google Scholar
     

  • Cervantes, J. et al. Effectiveness of platelet-rich plasma for androgenetic alopecia: A review of the literature. Skin Appendage Disord. 4, 1–11. https://doi.org/10.1159/000477671 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Nurden, A. T. Platelets, inflammation and tissue regeneration. Thromb. Haemost. 105(Suppl 1), S13-33. https://doi.org/10.1160/THS10-11-0720 (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nurden, A. T., Nurden, P., Sanchez, M., Andia, I. & Anitua, E. Platelets and wound healing. Front Biosci. 13, 3532–3548. https://doi.org/10.2741/2947 (2008).

    Article 
    PubMed 

    Google Scholar
     

  • Xu, J., Gou, L., Zhang, P., Li, H. & Qiu, S. Platelet-rich plasma and regenerative dentistry. Aust. Dent. J. 65, 131–142. https://doi.org/10.1111/adj.12754 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Marx, R. E. Platelet-rich plasma: Evidence to support its use. J. Oral Maxillofac. Surg. 62, 489–496. https://doi.org/10.1016/j.joms.2003.12.003 (2004).

    Article 
    PubMed 

    Google Scholar
     

  • Kunert, M. & Lukomska-Szymanska, M. Bio-inductive materials in direct and indirect pulp capping-a review article. Mater. Basel https://doi.org/10.3390/ma13051204 (2020).

    Article 

    Google Scholar
     

  • Shaheen, S. D., Niazy, M. A., Jamil, W. E. & Abu-Seida, A. M. Pulp tissue response to platelets rich plasma, platelets rich fibrin and mineral trioxide aggregate as pulp capping materials. Al-Azhar Dental J. Girls 8, 561–570 (2021).

    Article 

    Google Scholar
     

  • Moradi, S., Saghravanian, N., Moushekhian, S., Fatemi, S. & Forghani, M. Immunohistochemical evaluation of fibronectin and tenascin following direct pulp capping with mineral trioxide aggregate, platelet-rich plasma and propolis in dogs’ teeth. Iran Endod. J. 10, 188–192. https://doi.org/10.7508/iej.2015.03.009 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Du Sert, N. P. et al. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 20. PLoS Biol. 18(7), e3000411. https://doi.org/10.1371/journal.pbio.3000411 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Care, I.O.L.A.R.C.O. & Animals, U.O.L. Guide for the care and use of laboratory animals. (US Department of Health and Human Services, Public Health Service, National …, 1986).

  • Faul, F., Erdfelder, E., Lang, A. G. & Buchner, A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav. Res. Methods 39, 175–191. https://doi.org/10.3758/bf03193146 (2007).

    Article 
    PubMed 

    Google Scholar
     

  • Farghali, H. A. et al. Corneal ulcer in dogs and cats: Novel clinical application of regenerative therapy using subconjunctival injection of autologous platelet-rich plasma. Front Vet. Sci. 8, 641265. https://doi.org/10.3389/fvets.2021.641265 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • McKelvey, D. & Hollingshead, K. W. Small animal anesthesia & analgesia. (Mosby, 2000).

  • Haydari, M. et al. Comparing the effect of 0.06%-, 0.12% and 0.2% Chlorhexidine on plaque, bleeding and side effects in an experimental gingivitis model: A parallel group, double masked randomized clinical trial. BMC Oral Health. 17, 1–8. https://doi.org/10.1186/s12903-017-0400-7 (2017).

    Article 

    Google Scholar
     

  • Nowicka, A., Wilk, G., Lipski, M., Kolecki, J. & Buczkowska-Radlinska, J. Tomographic evaluation of reparative dentin formation after direct pulp capping with Ca(OH)2, MTA, Biodentine, and dentin bonding system in human teeth. J. Endod. 41, 1234–1240. https://doi.org/10.1016/j.joen.2015.03.017 (2015).

    Article 
    PubMed 

    Google Scholar
     

  • De Rossi, A. et al. Comparison of pulpal responses to pulpotomy and pulp capping with biodentine and mineral trioxide aggregate in dogs. J. Endod. 40, 1362–1369. https://doi.org/10.1016/j.joen.2014.02.006 (2014).

    Article 
    PubMed 

    Google Scholar
     

  • Akhavan, A., Arbabzadeh, F., Bouzari, M., Razavi, S. M. & Davoudi, A. Pulp response following direct pulp capping with dentin adhesives and mineral trioxide aggregate. An. Animal Study. Iran Endod. J. 12, 226–230. https://doi.org/10.22037/iej.2017.44 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25, 402–408. https://doi.org/10.1006/meth.2001.1262 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lin, L. M. & Rosenberg, P. A. Repair and regeneration in endodontics. Int. Endod. J. 44, 889–906. https://doi.org/10.1111/j.1365-2591.2011.01915.x (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nowicka, A. et al. Clinical and histological evaluation of direct pulp capping on human pulp tissue using a dentin adhesive system. Biomed. Res. Int. 2016, 2591273. https://doi.org/10.1155/2016/2591273 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Weber, M. T., Stratz, N., Fleiner, J., Schulze, D. & Hannig, C. Possibilities and limits of imaging endodontic structures with CBCT. Swiss Dent J 125, 293–311 (2015).

    PubMed 

    Google Scholar
     

  • Patel, K., Mannocci, F. & Patel, S. The assessment and management of external cervical resorption with periapical radiographs and cone-beam computed tomography: A clinical study. J. Endod. 42, 1435–1440. https://doi.org/10.1016/j.joen.2016.06.014 (2016).

    Article 
    PubMed 

    Google Scholar
     

  • Muruganandhan, J. et al. Comparison of four dental pulp-capping agents by cone-beam computed tomography and histological techniques—a split-mouth design ex vivo study. Appl. Sci. 11, 3045 (2021).

    Article 
    CAS 

    Google Scholar
     

  • Ather, A., Patel, B., Gelfond, J. A. L. & Ruparel, N. B. Outcome of pulpotomy in permanent teeth with irreversible pulpitis: A systematic review and meta-analysis. Sci. Rep. 12, 19664. https://doi.org/10.1038/s41598-022-20918-w (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Holiel, A. A., Mahmoud, E. M. & Abdel-Fattah, W. M. Tomographic evaluation of direct pulp capping using a novel injectable treated dentin matrix hydrogel: A 2-year randomized controlled clinical trial. Clin. Oral Investig. 25, 4621–4634. https://doi.org/10.1007/s00784-021-03775-1 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Mehrvarzfar, P., Abbott, P. V., Mashhadiabbas, F., Vatanpour, M. & Tour, S. S. Clinical and histological responses of human dental pulp to MTA and combined MTA/treated dentin matrix in partial pulpotomy. Aust. Endod. J. 44(1), 46–53. https://doi.org/10.1111/aej.12217 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Petrovic, V., Pejcic, N. & Cakic, S. The influence of different therapeutic modalities and platelet rich plasma on apexogenesis: A preliminary study in monkeys. Adv. Clin. Exp. Med. 22, 469–479 (2013).

    PubMed 

    Google Scholar
     

  • Shobana, S., Kavitha, M. & Srinivasan, N. Efficacy of platelet rich plasma and platelet rich fibrin for direct pulp capping in adult patients with carious pulp exposure-a randomised controlled trial. Eur. Endod. J. 7, 114–121. https://doi.org/10.14744/eej.2021.04834 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dammaschke, T., Nowicka, A., Lipski, M. & Ricucci, D. Histological evaluation of hard tissue formation after direct pulp capping with a fast-setting mineral trioxide aggregate (RetroMTA) in humans. Clin. Oral Investig. 23, 4289–4299. https://doi.org/10.1007/s00784-019-02876-2 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Tziafas, D., Pantelidou, O., Alvanou, A., Belibasakis, G. & Papadimitriou, S. The dentinogenic effect of mineral trioxide aggregate (MTA) in short-term capping experiments. Int. Endod. J. 35, 245–254. https://doi.org/10.1046/j.1365-2591.2002.00471.x (2002).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yamada, M. et al. Mineral trioxide aggregate (MTA) upregulates the expression of DMP1 in direct pulp capping in the rat molar. Mater. Basel https://doi.org/10.3390/ma14164640 (2021).

    Article 

    Google Scholar
     

  • Smith, A. J. et al. Reactionary dentinogenesis. Int. J. Dev. Biol. 39, 273–280 (1995).

    CAS 
    PubMed 

    Google Scholar
     

  • Ricucci, D., Loghin, S., Lin, L. M., Spangberg, L. S. & Tay, F. R. Is hard tissue formation in the dental pulp after the death of the primary odontoblasts a regenerative or a reparative process?. J. Dent. 42, 1156–1170. https://doi.org/10.1016/j.jdent.2014.06.012 (2014).

    Article 
    PubMed 

    Google Scholar
     

  • Fisher, L. W. & Fedarko, N. S. Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins. Connect Tissue Res. 44(Suppl 1), 33–40 (2003).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gullard, A. et al. MEPE localization in the craniofacial complex and function in tooth dentin formation. J. Histochem. Cytochem. 64, 224–236. https://doi.org/10.1369/0022155416635569 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yuan, G. et al. Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo. Sci. Rep. 7, 42449. https://doi.org/10.1038/srep42449 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Duverger, O. et al. Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp. J. Biol. Chem. 287, 12230–12240. https://doi.org/10.1074/jbc.M111.326900 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sejersen, T. & Lendahl, U. Transient expression of the intermediate filament nestin during skeletal muscle development. J. Cell Sci. 106(Pt 4), 1291–1300. https://doi.org/10.1242/jcs.106.4.1291 (1993).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • About, I., Laurent-Maquin, D., Lendahl, U. & Mitsiadis, T. A. Nestin expression in embryonic and adult human teeth under normal and pathological conditions. Am. J. Pathol. 157, 287–295. https://doi.org/10.1016/S0002-9440(10)64539-7 (2000).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Aryal, Y. P. et al. Facilitating reparative dentin formation using apigenin local delivery in the exposed pulp cavity. Front Physiol. 12, 773878. https://doi.org/10.3389/fphys.2021.773878 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sarkar, N. K., Caicedo, R., Ritwik, P., Moiseyeva, R. & Kawashima, I. Physicochemical basis of the biologic properties of mineral trioxide aggregate. J. Endod. 31, 97–100. https://doi.org/10.1097/01.don.0000133155.04468.41 (2005).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Aeinehchi, M., Eslami, B., Ghanbariha, M. & Saffar, A. S. Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: a preliminary report. Int. Endod. J. 36, 225–231. https://doi.org/10.1046/j.1365-2591.2003.00652.x (2003).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Laurent, P., Camps, J. & About, I. Biodentine(TM) induces TGF-beta1 release from human pulp cells and early dental pulp mineralization. Int. Endod. J. 45, 439–448. https://doi.org/10.1111/j.1365-2591.2011.01995.x (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Fridland, M. & Rosado, R. MTA solubility: A long term study. J. Endod. 31, 376–379. https://doi.org/10.1097/01.don.0000140566.97319.3e (2005).

    Article 
    PubMed 

    Google Scholar
     

  • Accorinte, M. L. et al. Response of human dental pulp capped with MTA and calcium hydroxide powder. Oper. Dent 33, 488–495. https://doi.org/10.2341/07-143 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Choi, H. M. et al. The cheapest and easiest way to make platelet-rich plasma preparation. Arch. Aesthet. Plast. Surg. 21, 12–17 (2015).

    Article 

    Google Scholar
     

  • Kevy, S. V. & Jacobson, M. S. Comparison of methods for point of care preparation of autologous platelet gel. J. Extra Corpor. Technol. 36, 28–35 (2004).

    Article 
    PubMed 

    Google Scholar
     

  • Anila, S. & Nandakumar, K. Applications of platelet rich plasma for regenerative therapy in periodontics. Trends Biomater. Artif. Org. 20, 78–84 (2006).


    Google Scholar
     



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