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Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth – Cell Death Discovery


  • Su CY, Ming QL, Rahman K, Han T, Qin LP. Salvia miltiorrhiza: traditional medicinal uses, chemistry, and pharmacology. Chin J Nat Med. 2015;13:163–82.

    CAS 
    PubMed 

    Google Scholar
     

  • Pan X, Niu G, Liu H. Microwave-assisted extraction of tanshinones from Salvia miltiorrhiza bunge with analysis by high-performance liquid chromatography. J Chromatogr A. 2001;922:371–5.

    CAS 
    PubMed 

    Google Scholar
     

  • Yang L, Guo H, Dong L, Wang L, Liu C, Wang X. Tanshinone IIA inhibits the growth, attenuates the stemness and induces the apoptosis of human glioma stem cells. Oncol Rep. 2014;32:1303–11.

    CAS 
    PubMed 

    Google Scholar
     

  • Yen JH, Huang ST, Huang HS, Fong YC, Wu YY, Chiang JH, et al. HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells. Cell Death Dis. 2018;9:1003.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Teng Z, Xu S, Lei Q. Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB152 in vivo and in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway. Oncol Rep. 2020;43:503–15.

    CAS 
    PubMed 

    Google Scholar
     

  • Zhou J, Jiang YY, Wang XX, Wang HP, Chen H, Wu YC, et al. Tanshinone IIA suppresses ovarian cancer growth through inhibiting malignant properties and angiogenesis. Ann Transl Med. 2020;8:1295.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Su CC, Chiu TL. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. Oncol Rep. 2016;36:1173–9.

    CAS 
    PubMed 

    Google Scholar
     

  • Zhang Y, Geng Y, He J, Wu D, Zhang T, Xue L, et al. Tanshinone IIA induces apoptosis and autophagy in acute monocytic leukemia via downregulation of PI3K/Akt pathway. Am J Transl Res. 2019;11:2995–3006.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhu H, Zhao N, Jiang M. Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway. Biochem Cell Biol. 2021;99:741–9.

    CAS 
    PubMed 

    Google Scholar
     

  • Bohn A, Braley A, Rodriguez de la Vega P, Zevallos JC, Barengo NC. The association between race and survival in glioblastoma patients in the US: a retrospective cohort study. PLoS ONE. 2018;13:e0198581.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, et al. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarkers Prev. 2014;23:1985–96.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Batash R, Asna N, Schaffer P, Francis N, Schaffer M. Glioblastoma multiforme, diagnosis and treatment; recent literature review. Curr Med Chem. 2017;24:3002–9.

    CAS 
    PubMed 

    Google Scholar
     

  • Zhou X, Lv L, Tan Y, Zhang Z, Wei S, Xiao S. Tanshinone IIA sensitizes TRAIL-induced apoptosis in glioblastoma through inducing the expression of death receptors (and suppressing STAT3 activation). Brain Res. 2021;1766:147515.

    CAS 
    PubMed 

    Google Scholar
     

  • Jian S, Chen L, Minxue L, Hongmin C, Ronghua T, Xiaoxuan F, et al. Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen speciesdependent pathway. Int J Mol Med. 2020;45:983–92.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Di Cesare Mannelli L, Piccolo M, Maione F, Ferraro MG, Irace C, De Feo V, et al. Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy. Biomed Pharmacother. 2018;105:1042–9.

    PubMed 

    Google Scholar
     

  • Song M, Hang TJ, Zhang Z, Chen HY. Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat. Eur J Pharm Sci. 2007;32:247–53.

    CAS 
    PubMed 

    Google Scholar
     

  • Perry CJ, Finch P, Muller-Taubenberger A, Leung KY, Warren EC, Damstra-Oddy J, et al. A new mechanism for cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models. Br J Pharmacol. 2020;177:912–28.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schaf J, Damstra-Oddy J, Williams RSB. Dictyostelium discoideum as a pharmacological model system to study the mechanisms of medicinal drugs and natural products. Int J Dev Biol. 2019;63:541–50.

    CAS 
    PubMed 

    Google Scholar
     

  • Warren EC, Dooves S, Lugara E, Damstra-Oddy J, Schaf J, Heine VM, et al. Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling. Proc Natl Acad Sci USA. 2020;117:23617–25.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Damstra-Oddy JL, Warren EC, Perry CJ, Desfougeres Y, Fitzpatrick JK, Schaf J, et al. Phytocannabinoid-dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity. Br J Pharmacol. 2021;178:1149–63.

    CAS 
    PubMed 

    Google Scholar
     

  • Pears CJ, Brustel J, Lakin ND. Dictyostelium discoideum as a model to assess genome stability through DNA repair. Front Cell Dev Biol. 2021;9:752175.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chang P, Orabi B, Deranieh RM, Dham M, Hoeller O, Shimshoni JA, et al. The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. Dis Model Mech. 2012;5:115–24.

    CAS 
    PubMed 

    Google Scholar
     

  • Schoeler NE, Orford M, Vivekananda U, Simpson Z, Van de Bor B, Smith H, et al. K.Vita: a feasibility study of a blend of medium chain triglycerides to manage drug-resistant epilepsy. Brain Commun. 2021;3:fcab160.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu Z, Zhu W, Kong X, Chen X, Sun X, Zhang W, et al. Tanshinone IIA inhibits glucose metabolism leading to apoptosis in cervical cancer. Oncol Rep. 2019;42:1893–903.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jaiswal P, Majithia AR, Rosel D, Liao XH, Khurana T, Kimmel AR. Integrated actions of mTOR complexes 1 and 2 for growth and development of Dictyostelium. Int J Dev Biol. 2019;63:521–7.

    CAS 
    PubMed 

    Google Scholar
     

  • Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease. Cell. 2017;169:361–71.

    CAS 
    PubMed 

    Google Scholar
     

  • Loovers HM, Postma M, Keizer-Gunnink I, Huang YE, Devreotes PN, Van Haastert PJ. Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol Biol Cell. 2006;17:1503–13.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao W, Sachsenmeier K, Zhang L, Sult E, Hollingsworth RE, Yang H. A new bliss independence model to analyze drug combination data. J Biomol Screen. 2014;19:817–21.

    PubMed 

    Google Scholar
     

  • Ding L, Ding L, Wang S, Wang S, Wang W, Wang W, et al. Tanshinone IIA affects autophagy and apoptosis of glioma cells by inhibiting phosphatidylinositol 3-kinase/akt/mammalian target of rapamycin signaling pathway. Pharmacology. 2017;99:188–95.

    CAS 
    PubMed 

    Google Scholar
     

  • Jiang Y, Hu F, Li Q, Shen C, Yang J, Li M. Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis. Int Immunopharmacol. 2019;77:105968.

    CAS 
    PubMed 

    Google Scholar
     

  • Su CC. Tanshinone IIA can inhibit MiaPaCa2 human pancreatic cancer cells by dual blockade of the Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways. Oncol Rep. 2018;40:3102–11.

    CAS 
    PubMed 

    Google Scholar
     

  • Williams TD, Peak-Chew SY, Paschke P, Kay RR. Akt and SGK protein kinases are required for efficient feeding by macropinocytosis. J Cell Sci. 2019;132:jcs224998.

    PubMed 

    Google Scholar
     

  • Kamimura Y, Tang M, Devreotes P. Assays for chemotaxis and chemoattractant-stimulated TorC2 activation and PKB substrate phosphorylation in Dictyostelium. Methods Mol Biol. 2009;571:255–70.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rosel D, Khurana T, Majithia A, Huang X, Bhandari R, Kimmel AR. TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing. J Cell Sci. 2012;125:37–48.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shen K, Sabatini DM. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms. Proc Natl Acad Sci USA. 2018;115:9545–50.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rafia S, Saran S. Sestrin-like protein from Dictyostelium discoideum is involved in autophagy under starvation stress. Microbiol Res. 2019;220:61–71.

    CAS 
    PubMed 

    Google Scholar
     

  • Fiani B, Covarrubias C, Onyedimma C, Jarrah R. Neurocytological advances in the treatment of glioblastoma multiforme. Cureus. 2021;13:e16301.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Heffron TP, Ndubaku CO, Salphati L, Alicke B, Cheong J, Drobnick J, et al. Discovery of clinical development candidate GDC-0084, a brain penetrant inhibitor of PI3K and mTOR. ACS Med Chem Lett. 2016;7:351–6.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Syed N, Langer J, Janczar K, Singh P, Lo Nigro C, Lattanzio L, et al. Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma. Cell Death Dis. 2013;4:e458.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Akbasak A, Oldfield EH, Saris SC. Expression and modulation of major histocompatibility antigens on murine primary brain tumor in vitro. J Neurosurg. 1991;75:922–9.

    CAS 
    PubMed 

    Google Scholar
     

  • Orcheston-Findlay L, Bax S, Utama R, Engel M, Govender D, O’Neill G. Advanced spheroid, tumouroid and 3D bioprinted in-vitro models of adult and paediatric glioblastoma. Int J Mol Sci. 2021;22:2962.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guyon J, Andrique L, Pujol N, Rosland GV, Recher G, Bikfalvi A, et al. A 3D Spheroid Model for Glioblastoma. J Vis Exp. 2020;158. https://doi.org/10.3791/60998.

  • Zhu M, Jin Q, Xin Y. Recent clinical advances in PI3K inhibitors on colorectal cancer. Pharmazie. 2021;76:568–73.

    CAS 
    PubMed 

    Google Scholar
     

  • Lee JJ, Loh K, Yap YS. PI3K/Akt/mTOR inhibitors in breast cancer. Cancer Biol Med. 2015;12:342–54.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, et al. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 2000;60:3504–13.

    CAS 
    PubMed 

    Google Scholar
     

  • Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, et al. Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. Nat Commun. 2016;7:11971.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, et al. The somatic genomic landscape of glioblastoma. Cell. 2013;155:462–77.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, et al. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 2014;9:1–8.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Abtahi SH, Mohammadi MH, Allahbakhshian Farsani M, Aghelan Z, Salari S. Evaluation of sestrin 2, adiponectin, AMPK, and mTOR genes expression in acute myeloid leukemia patients. Iran J Biotechnol. 2021;19:e2860.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Greenwell IB, Ip A, Cohen JB. PI3K inhibitors: understanding toxicity mechanisms and management. Oncology. 2017;31:821–8.

    PubMed 

    Google Scholar
     

  • Wright SCE, Vasilevski N, Serra V, Rodon J, Eichhorn PJA. Mechanisms of resistance to PI3K inhibitors in cancer: adaptive responses, drug tolerance and cellular plasticity. Cancers. 2021;13:1538.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Juric D, Castel P, Griffith M, Griffith OL, Won HH, Ellis H, et al. Convergent loss of PTEN leads to clinical resistance to a PI(3)Kalpha inhibitor. Nature. 2015;518:240–4.

    CAS 
    PubMed 

    Google Scholar
     

  • Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT. The PI3K pathway in human disease. Cell. 2017;170:605–35.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kwan P, Brodie MJ. Combination therapy in epilepsy: when and what to use. Drugs. 2006;66:1817–29.

    CAS 
    PubMed 

    Google Scholar
     

  • Nurgali K, Jagoe RT, Abalo R. Editorial: adverse effects of cancer chemotherapy: anything new to improve tolerance and reduce sequelae? Front Pharmacol. 2018;9:245.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sablina AA, Budanov AV, Ilyinskaya GV, Agapova LS, Kravchenko JE, Chumakov PM. The antioxidant function of the p53 tumor suppressor. Nat Med. 2005;11:1306–13.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wen PY, De Groot J, Basttiste JD, Goldlust SA, Garner JS, Simpson J, et al. Phase 2a study to evaluate the safety, pharmacokinetics, and clinical activity of the PI3K / mTOR inhibitor paxalisib (GDC-0084) given to glioblastoma (GBM) patients with unmethylated MGMT promotor status. Neuro Oncol. 2019;21:iii35.

    PubMed Central 

    Google Scholar
     

  • Wen PY, Cloughesy TF, Olivero AG, Morrissey KM, Wilson TR, Lu X, et al. First-in-human phase I study to evaluate the brain-penetrant PI3K/mTOR inhibitor GDC-0084 in patients with progressive or recurrent high-grade glioma. Clin Cancer Res. 2020;26:1820–8.

    CAS 
    PubMed 

    Google Scholar
     

  • Li X, Jia Q, Zhou Y, Jiang X, Song L, Wu Y, et al. Tanshinone IIA attenuates the stemness of breast cancer cells via targeting the miR-125b/STARD13 axis. Exp Hematol Oncol. 2022;11:2.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Qiao P, Xu J, Liu X, Li X. Tanshinone IIA improves ventricular remodeling following cardiac infarction by regulating miR-205-3p. Dis Markers. 2021;2021:8740831.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lam BY, Lo AC, Sun X, Luo HW, Chung SK, Sucher NJ. Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice. Phytomedicine. 2003;10:286–91.

    CAS 
    PubMed 

    Google Scholar
     

  • Chen X, Zhou ZW, Xue CC, Li XX, Zhou SF. Role of P-glycoprotein in restricting the brain penetration of tanshinone IIA, a major active constituent from the root of Salvia miltiorrhiza Bunge, across the blood-brain barrier. Xenobiotica. 2007;37:635–78.

    CAS 
    PubMed 

    Google Scholar
     

  • Wang B, Wang H, Wang E, Yan W, Ye W, Li P. Isolation and structure characterization of related impurities in Sodium Tanshinone IIA Sulfonate by LC/ESI-MS(n) and NMR. J Pharm Biomed Anal. 2012;67-68:36–41.

    CAS 
    PubMed 

    Google Scholar
     

  • Zhang B, Yu P, Su E, Jia J, Zhang C, Xie S, et al. Sodium tanshinone IIA sulfonate improves adverse ventricular remodeling post MI by reducing myocardial necrosis, modulating inflammation and promoting angiogenesis. Curr Pharm Des. 2022;28:751–9.

    CAS 
    PubMed 

    Google Scholar
     

  • Zhou H, Zhao Y, Peng W, Han W, Wang Z, Ren X, et al. Effect of sodium tanshinone IIA sulfonate injection on blood lipid in patients with coronary heart disease: a systematic review and meta-analysis of randomized clinical trials. Front Cardiovasc Med. 2021;8:770746.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou ZY, Zhao WR, Zhang J, Chen XL, Tang JY. Sodium tanshinone IIA sulfonate: a review of pharmacological activity and pharmacokinetics. Biomed Pharmacother. 2019;118:109362.

    CAS 
    PubMed 

    Google Scholar
     

  • Qin WW, Wang L, Jiao Z, Wang B, Wang CY, Qian LX, et al. Lower clearance of sodium tanshinone IIA sulfonate in coronary heart disease patients and the effect of total bilirubin: a population pharmacokinetics analysis. Chin J Nat Med. 2019;17:218–26.

    CAS 
    PubMed 

    Google Scholar
     

  • Zhu S, Ma AH, Zhu Z, Adib E, Rao T, Li N, et al. Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer. J Immunother Cancer. 2021;9:e002917.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • van der Ploeg P, Uittenboogaard A, Thijs AMJ, Westgeest HM, Boere IA, Lambrechts S, et al. The effectiveness of monotherapy with PI3K/AKT/mTOR pathway inhibitors in ovarian cancer: a meta-analysis. Gynecol Oncol. 2021;163:433–44.

    PubMed 

    Google Scholar
     

  • Leung JH, Leung HWC, Wang SY, Huang SS, Chan ALF. Efficacy and safety of CDK4/6 and PI3K/AKT/mTOR inhibitors as second-line treatment in postmenopausal patients with hormone receptor-positive, HER-2-negative metastatic breast cancer: a network meta-analysis. Expert Opin Drug Saf. 2021;20:949–57.

    CAS 
    PubMed 

    Google Scholar
     

  • Li H, Prever L, Hirsch E, Gulluni F. Targeting PI3K/AKT/mTOR signaling pathway in breast cancer. Cancers. 2021;13:3517.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Huang H, Zhu J, Lin Y, Zhang Z, Liu J, Wang C, et al. The potential diagnostic value of extracellular vesicle miRNA for human non-small cell lung cancer: a systematic review and meta-analysis. Expert Rev Mol Diagn. 2021;21:823–36.

    CAS 
    PubMed 

    Google Scholar
     

  • Giordano A, Romano A. Inhibition of human in-stent restenosis: a molecular view. Curr Opin Pharmacol. 2011;11:372–7.

    CAS 
    PubMed 

    Google Scholar
     

  • Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D’Arcangelo G. Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. Dis Model Mech. 2009;2:389–98.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kim JK, Cho J, Kim SH, Kang HC, Kim DS, Kim VN, et al. Brain somatic mutations in MTOR reveal translational dysregulations underlying intractable focal epilepsy. J Clin Invest. 2019;129:4207–23.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lim JS, Kim WI, Kang HC, Kim SH, Park AH, Park EK, et al. Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy. Nat Med. 2015;21:395–400.

    CAS 
    PubMed 

    Google Scholar
     

  • Karalis V, Bateup HS. Current approaches and future directions for the treatment of mTORopathies. Dev Neurosci. 2021;43:143–58.

    CAS 
    PubMed 

    Google Scholar
     

  • Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature. 2004;431:200–5.

    CAS 
    PubMed 

    Google Scholar
     

  • Davidson AJ, King JS, Insall RH. The use of streptavidin conjugates as immunoblot loading controls and mitochondrial markers for use with Dictyostelium discoideum. Biotechniques. 2013;55:39–41.

    CAS 
    PubMed 

    Google Scholar
     

  • Sekine R, Kawata T, Muramoto T. CRISPR/Cas9 mediated targeting of multiple genes in Dictyostelium. Sci Rep. 2018;8:8471.

    PubMed 
    PubMed Central 

    Google Scholar
     



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