Fuller R, Landrigan PJ, Balakrishnan K, Bathan G, Bose-O’Reilly S, Brauer M, et al. Pollution and health: a progress update. Lancet Planet Health. 2022;6:e535–547.
Southerland VA, Brauer M, Mohegh A, Hammer MS, van Donkelaar A, Martin RV, et al. Global urban temporal trends in fine particulate matter (PM2·5) and attributable health burdens: estimates from global datasets. Lancet Planet Health [Internet]. 2022. https://doi.org/10.1016/S2542-5196(21)00350-8.
Jbaily A, Zhou X, Liu J, Lee T-H, Kamareddine L, Verguet S, et al. Air pollution exposure disparities across US population and income groups. Nature. 2022;601:228–33.
Earnshaw VA, Rosenthal L, Lewis JB, Stasko EC, Tobin JN, Lewis TT, et al. Maternal experiences with everyday discrimination and infant birth weight: a test of mediators and moderators among young, urban women of color. Ann Behav Med. 2013;45:13–23.
McGuinn LA, Windham GC, Messer LC, Di Q, Schwartz J, Croen LA, et al. Air pollution, neighborhood deprivation, and autism spectrum disorder in the Study to Explore Early Development. Environ Epidemiol [Internet]. 2019. https://doi.org/10.1097/ee9.0000000000000067.
Rahman MM, Shu Y-H, Chow T, Lurmann FW, Yu X, Martinez MP, et al. Prenatal exposure to air pollution and autism spectrum disorder: sensitive windows of exposure and sex differences. Environ Health Perspect. 2022;130:17008.
Carter SA, Rahman MM, Lin JC, Shu Y-H, Chow T, Yu X, et al. In utero exposure to near-roadway air pollution and autism spectrum disorder in children. Environ Int. 2022;158:106898.
Volk HE, Lurmann F, Penfold B, Hertz-Picciotto I, McConnell R. Traffic-related air pollution, particulate matter, and autism. JAMA Psychiatry. 2013;70:71–7.
Roberts AL, Koenen KC, Lyall K, Ascherio A, Weisskopf MG. Women’s posttraumatic stress symptoms and autism spectrum disorder in their children. Res Autism Spectr Disord. 2014;8:608–16.
Kinney DK, Munir KM, Crowley DJ, Miller AM. Prenatal stress and risk for autism. Neurosci Biobehav Rev. 2008;32:1519–32.
Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z, et al. Prevalence of autism spectrum disorder among children aged 8 years – autism and developmental disabilities monitoring network, 11 Sites, United States, 2014. MMWR Surveill Summ. 2018;67:1–23.
Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16:626–38.
Supekar K, Kochalka J, Schaer M, Wakeman H, Qin S, Padmanabhan A, et al. Deficits in mesolimbic reward pathway underlie social interaction impairments in children with autism. Brain. 2018;141:2795–805.
Walsh JJ, Christoffel DJ, Heifets BD, Ben-Dor GA, Selimbeyoglu A, Hung LW, et al. 5-HT release in nucleus accumbens rescues social deficits in mouse autism model. Nature. 2018;560:589–94.
Polk M, Ikuta T. Disrupted functional connectivity between the nucleus accumbens and posterior cingulate cortex in autism spectrum disorder. Neuroreport. 2022;33:43–7.
Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, et al. Natural neural projection dynamics underlying social behavior. Cell. 2014;157:1535–51.
Kopec AM, Smith CJ, Ayre NR, Sweat SC, Bilbo SD. Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats. Nat Commun. 2018;9:3769.
Manduca A, Servadio M, Damsteegt R, Campolongo P, Vanderschuren LJ, Trezza V. Dopaminergic neurotransmission in the nucleus accumbens modulates social play behavior in rats. Neuropsychopharmacology. 2016;41:2215–23.
Block ML, Calderon-Garciduenas L. Air Pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci. 2009;32:506–16.
Dziabis JE, Bilbo SD. Microglia and sensitive periods in brain development. Curr Top Behav Neurosci [Internet]. 2021. https://doi.org/10.1007/7854_2021_242.
Sherwin E, Bordenstein SR, Quinn JL, Dinan TG, Cryan JF. Microbiota and the social brain. Science [Internet]. 2019;366:eaar2016.
Kang D-W, Adams JB, Vargason T, Santiago M, Hahn J, Krajmalnik-Brown R. Distinct fecal and plasma metabolites in children with autism spectrum disorders and their modulation after microbiota transfer therapy. mSphere [Internet]. 2020. https://doi.org/10.1128/mSphere.00314-20.
Kang D-W, Adams JB, Coleman DM, Pollard EL, Maldonado J, McDonough-Means S, et al. Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota. Sci Rep. 2019;9:5821.
Yap CX, Henders AK, Alvares GA, Wood DLA, Krause L, Tyson GW, et al. Autism-related dietary preferences mediate autism-gut microbiome associations. Cell. 2021;184:5916–31.e17.
Erny D, Hrabě de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, et al. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015;18:965–77.
Thion MS, Low D, Silvin A, Chen J, Grisel P, Schulte-Schrepping J, et al. Microbiome influences prenatal and adult microglia in a sex-specific manner. Cell. 2018;172:500–16.e16.
Buffington SA, Di Prisco GV, Auchtung TA, Ajami NJ, Petrosino JF, Costa-Mattioli M. Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell. 2016;165:1762–75.
Sgritta M, Dooling SW, Buffington SA, Momin EN, Francis MB, Britton RA, et al. Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder. Neuron. 2019;101:246–59.e6.
van den Brule S, Rappe M, Ambroise J, Bouzin C, Dessy C, Paquot A, et al. Diesel exhaust particles alter the profile and function of the gut microbiota upon subchronic oral administration in mice. Part Fibre Toxicol. 2021;18:7.
Liu Y, Wang T, Si B, Du H, Liu Y, Waqas A, et al. Intratracheally instillated diesel PM2.5 significantly altered the structure and composition of indigenous murine gut microbiota. Ecotoxicol Environ Saf. 2021;210:111903.
Bolton JL, Huff NC, Smith SH, Mason SN, Foster WM, Auten RL, et al. Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice. Environ Health Perspect. 2013;121:1075–82.
Block CL, Eroglu O, Mague SD, Smith CJ, Ceasrine AM, Sriworarat C, et al. Prenatal environmental stressors impair postnatal microglia function and adult behavior in males, Cell Reports, 2022;40:111161.
Rice CJ, Sandman CA, Lenjavi MR, Baram TZ. A novel mouse model for acute and long-lasting consequences of early life stress. Endocrinology. 2008;149:4892–900.
Smith CJW, Wilkins KB, Mogavero JN, Veenema AH. Social novelty investigation in the juvenile rat: modulation by the μ-Opioid system. J Neuroendocrinol. 2015;27:752–64.
Hanamsagar R, Alter MD, Block CS, Sullivan H, Bolton JL, Bilbo SD. Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity. Glia. 2017;65:1504–20.
Bordt EA, Block CL, Petrozziello T, Sadri-Vakili G, Smith CJ, Edlow AG, et al. Isolation of microglia from mouse or human tissue. STAR Protoc [Internet]. 2020. https://doi.org/10.1016/j.xpro.2020.100035.
Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550.
Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29:15–21.
Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014;30:923–30.
Blighe K, Rana S, Turkes E, Ostendorf B, Lewis M. EnhancedVolcano: publication-ready volcano plots with enhanced colouring and labeling [internet]. Bioconductor version: Release (3.12). 2021.
Franklin, K & Paxinos G. Franklin and Paxinos Mouse Brain Atlas, 5th Edition, Academic Press 2019.
Parada AE, Needham DM, Fuhrman JA. Every base matters: assessing small subunit rRNA primers for marine microbiomes with mock communities, time series and global field samples. Environ Microbiol. 2016;18:1403–14.
Caporaso JG, Lauber CL, Walters WA, Berg-Lyons D, Huntley J, Fierer N, et al. Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms. ISME J. 2012;6:1621–4.
Caporaso JG, Lauber CL, Walters WA, Berg-Lyons D, Lozupone CA, Turnbaugh PJ, et al. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc Natl Acad Sci USA. 2011;108:4516–22.
Hammer O, Harper DA, Ryan PD. PAST: paleontological statistics software package for education and data analysis. Palaeontol Electron. 2001;4:9–18.
Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJA, Holmes SP. DADA2: High-resolution sample inference from Illumina amplicon data. Nat Methods. 2016;13:581–3.
Katoh K, Misawa K, Kuma K-I, Miyata T. MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Res. 2002;30:3059–66.
Bokulich NA, Dillon MR, Zhang Y, Rideout JR, Bolyen E, Li H, et al. q2-longitudinal: longitudinal and paired-sample analyses of microbiome data. mSystems [Internet]. 2018. https://doi.org/10.1128/mSystems.00219-18.
McDonald D, Price MN, Goodrich J, Nawrocki EP, DeSantis TZ, Probst A, et al. An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea. ISME J. 2012;6:610–8.
Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, et al. Metagenomic biomarker discovery and explanation. Genome Biol. 2011;12:R60. Jun 24
Weinhard L, di Bartolomei G, Bolasco G, Machado P, Schieber NL, Neniskyte U, et al. Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction. Nat Commun. 2018;9:1228.
York EM, LeDue JM, Bernier L-P, MacVicar BA. 3DMorph automatic analysis of microglial morphology in three dimensions from ex vivo and in vivo imaging. eNeuro [Internet]. 2018. https://doi.org/10.1523/ENEURO.0266-18.2018.
Smith CJW, Mogavero JN, Tulimieri MT, Veenema AH. Involvement of the oxytocin system in the nucleus accumbens in the regulation of juvenile social novelty-seeking behavior. Horm Behav. 2017;93:94–8.
Smith CJW, Wilkins KB, Li S, Tulimieri MT, Veenema AH. Nucleus accumbens mu opioid receptors regulate context-specific social preferences in the juvenile rat. Psychoneuroendocrinology. 2018;89:59–68.
Folkes OM, Báldi R, Kondev V, Marcus DJ, Hartley ND, Turner BD, et al. An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability. J Clin Invest. 2020;130:1728–42.
Lefter R, Ciobica A, Timofte D, Stanciu C, Trifan A. A descriptive review on the prevalence of gastrointestinal disturbances and their multiple associations in autism spectrum disorder. Medicina [Internet]. 2019;56:11.
Nalbant K, Erden S, Yazar A, Kılınç İ. Investigation of the relation between epithelial barrier function and autism symptom severity in children with autism spectrum disorder. J Mol Neurosci [Internet]. 2022. https://doi.org/10.1007/s12031-021-01954-z.
Abrams GD, Bauer H, Sprinz H. Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice. Lab Investig. 1963;12:355–64.
Arike L, Seiman A, van der Post S, Rodriguez Piñeiro AM, Ermund A, Schütte A, et al. Protein turnover in epithelial cells and mucus along the gastrointestinal tract is coordinated by the spatial location and microbiota. Cell Rep. 2020;30:1077–87.e3.
Park J-H, Kotani T, Konno T, Setiawan J, Kitamura Y, Imada S, et al. Promotion of intestinal epithelial cell turnover by commensal bacteria: role of short-chain fatty acids. PLoS One. 2016;11:e0156334.
Cahill KM, Huo Z, Tseng GC, Logan RW, Seney ML. Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach. Sci Rep. 2018;8:9588.
Daft JG, Ptacek T, Kumar R, Morrow C, Lorenz RG. Cross-fostering immediately after birth induces a permanent microbiota shift that is shaped by the nursing mother. Microbiome. 2015;3:17.
Treichel NS, Prevoršek Z, Mrak V, Kostrić M, Vestergaard G, Foesel B, et al. Effect of the nursing mother on the gut microbiome of the offspring during early mouse development. Microb Ecol. 2019;78:517–27.
Daoust L, Choi BS-Y, Lacroix S, Rodrigues Vilela V, Varin TV, Dudonné S, et al. The postnatal window is critical for the development of sex-specific metabolic and gut microbiota outcomes in offspring. Gut Microbes. 2021;13:2004070.
Boukthir S, Aouididi F, Mazigh Mrad S, Fetni I, Bouyahya O, Gharsallah L, et al. Chronic gastritis in children. Tunis Med. 2007;85:756–60.
Yu Y, Su L, Wang X, Wang X, Xu C. Association between Helicobacter pylori infection and pathological changes in the gastric mucosa in Chinese children. Intern Med. 2014;53:83–8.
Strati F, Cavalieri D, Albanese D, De Felice C, Donati C, Hayek J, et al. New evidences on the altered gut microbiota in autism spectrum disorders. Microbiome. 2017;5:24.
Sharon G, Cruz NJ, Kang D-W, Gandal MJ, Wang B, Kim Y-M, et al. Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice. Cell. 2019;177:1600–18.e17.
Desbonnet L, Clarke G, Shanahan F, Dinan TG, Cryan JF. Microbiota is essential for social development in the mouse. Mol Psychiatry. 2014;19:146–8.
Hsaio EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013;155:1451–63.
Hayes LN, Kyongman A, Carloni E, Fangze L, Vincent E, Trippaers C, et al. Prenatal immune stress blunts microglia reactivity impairing neurocircuitry. Nature. 2022;610:327–34.
Castillo-Ruiz A, Cisternas CD, Sturgeon H, Forger NG. Birth triggers an inflammatory response in the neonatal periphery and brain. Brain Behav Immun. 2022;104:122–36.
Dodiya HB, Lutz HL, Weigle IQ, Patel P, Michalkiewicz J, Roman-Santiago CJ, et al. Gut microbiota-driven brain Aβ amyloidosis in mice requires microglia. J Exp Med. 2019;219:e20200895.