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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank – Nature Communications


  • Quigley, H. A. Number of people with glaucoma worldwide. Br. J. Ophthalmol. 80, 389–393 (1996).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gharahkhani, P. et al. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat. Commun. 12, 1258 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Goodacre, R., Vaidyanathan, S., Dunn, W. B., Harrigan, G. G. & Kell, D. B. Metabolomics by numbers: acquiring and understanding global metabolite data. Trends Biotechnol. 22, 245–252 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Roberts, L. D., Souza, A. L., Gerszten, R. E. & Clish, C. B. Targeted metabolomics. Curr. Protoc. Mol. Biol. Chapter 30 Unit 30.2.1–24 (2012).

  • Wang, Y., Hou, X. W., Liang, G. & Pan, C. W. Metabolomics in glaucoma: a systematic review. Investig. Ophthalmol. Vis. Sci. 62, 9 (2021).

    Article 
    CAS 

    Google Scholar
     

  • Gong, H. et al. Gut microbiota compositional profile and serum metabolic phenotype in patients with primary open-angle glaucoma. Exp. Eye Res. 191, 107921 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Javadiyan, S. et al. Elevation of serum asymmetrical and symmetrical dimethylarginine in patients with advanced glaucoma. Investig. Ophthalmol. Vis. Sci. 53, 1923–1927 (2012).

    Article 
    CAS 

    Google Scholar
     

  • Umeno, A. et al. Comprehensive measurements of hydroxylinoleate and hydroxyarachidonate isomers in blood samples from primary open-angle glaucoma patients and controls. Sci. Rep. 9, 1–11 (2019).

    Article 
    ADS 
    CAS 

    Google Scholar
     

  • Kouassi Nzoughet, J. et al. A data mining metabolomics exploration of glaucoma. Metabolites 10, 49 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Leruez, S. et al. A metabolomics profiling of glaucoma points to mitochondrial dysfunction, senescence, and polyamines deficiency. Investig. Ophthalmol. Vis. Sci. 59, 4355–4361 (2018).

    Article 
    CAS 

    Google Scholar
     

  • Burgess, L. G. et al. Metabolome-wide association study of primary open angle glaucoma. Investig. Ophthalmol. Vis. Sci. 56, 5020–5028 (2015).

    Article 
    CAS 

    Google Scholar
     

  • Cabrerizo, J., Urcola, J. A. & Vecino, E. Changes in the lipidomic profile of aqueous humor in open-angle glaucoma. J. Glaucoma 26, 349–355 (2017).

    Article 
    PubMed 

    Google Scholar
     

  • Myer, C. et al. Differentiation of soluble aqueous humor metabolites in primary open-angle glaucoma and controls. Exp. Eye Res. 194, 108024 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Buisset, A. et al. Metabolomic profiling of aqueous humor in glaucoma points to taurine and spermine deficiency: Findings from the Eye-D study. J. Proteome Res. 18, 1307–1315 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pan, C.-W. et al. Differential metabolic markers associated with primary open-angle glaucoma and cataract in human aqueous humor. BMC Ophthalmol. 20, 1–8 (2020).

    Article 

    Google Scholar
     

  • Rossi, C. et al. Multi-omics approach for studying tears in treatment-naïve glaucoma patients. Int. J. Mol. Sci. 20, 4029 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Boucard, C. C., Hoogduin, J. M., van der Grond, J. & Cornelissen, F. W. Occipital proton magnetic resonance spectroscopy (1H-MRS) reveals normal metabolite concentrations in retinal visual field defects. PLoS One 2, e222 (2007).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Khanna, R. K. et al. Metabolomics and lipidomics approaches in human tears: a systematic review. Surv. Ophthalmol. 67, 1229–1243 (2022).

    Article 
    PubMed 

    Google Scholar
     

  • Breda, J. B. et al. Metabolomic profiling of aqueous humor from glaucoma patients—the metabolomics in surgical ophthalmological patients (MISO) study. Exp. Eye Res. 201, 108268 (2020).

    Article 

    Google Scholar
     

  • Tang, Y. et al. Metabolomic profiling of aqueous humor and plasma in primary open-angle glaucoma patients points towards novel diagnostic and therapeutic strategy. Front. Pharmacol. 12, 621146 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kang, J. W., Park, B. & Cho, B. J. Comparison of risk factors for initial central scotoma versus initial peripheral scotoma in normal-tension glaucoma. Korean J. Ophthalmol. 29, 102–108 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kim, J. M., Kyung, H., Shim, S. H., Azarbod, P. & Caprioli, J. Location of Initial Visual Field Defects in Glaucoma and Their Modes of Deterioration. Investig. Ophthalmol. Vis. Sci. 56, 7956–7962 (2015).

    Article 
    CAS 

    Google Scholar
     

  • Park, S. C. et al. Initial parafoveal versus peripheral scotomas in glaucoma: risk factors and visual field characteristics. Ophthalmology 118, 1782–1789 (2011).

    Article 
    PubMed 

    Google Scholar
     

  • Stegemann, C. et al. Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study. Circulation 129, 1821–1831 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rhee, E. P. et al. Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J. Clin. Investig. 121, 1402–1411 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Umeno, A. et al. Comprehensive measurements of hydroxylinoleate and hydroxyarachidonate isomers in blood samples from primary open-angle glaucoma patients and controls. Sci. Rep. 9, 2171 (2019).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rossi, C. et al. Multi-omics approach for studying tears in treatment-naive glaucoma patients. Int. J. Mol. Sci. 20, 4029 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen, Y. Y. et al. Patients with primary open-angle glaucoma may develop ischemic heart disease more often than those without glaucoma: an 11-year population-based cohort study. PLoS One 11, e0163210 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Newman-Casey, P. A., Talwar, N., Nan, B., Musch, D. C. & Stein, J. D. The relationship between components of metabolic syndrome and open-angle glaucoma. Ophthalmology 118, 1318–1326 (2011).

    Article 
    PubMed 

    Google Scholar
     

  • Xu, M. et al. Plasma lipid levels and risk of primary open-angle glaucoma: a genetic study using Mendelian randomization. BMC Ophthalmol. 20, 390 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang, S. & Bao, X. Hyperlipidemia, blood lipid level, and the risk of glaucoma: a meta-analysis. Invest Ophthalmol. Vis. Sci. 60, 1028–1043 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Pertl, L. et al. Triglycerides and open angle glaucoma—a meta-analysis with meta-regression. Sci. Rep. 7, 7829 (2017).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rasoulinejad, S. A. et al. The association between primary open angle glaucoma and clustered components of metabolic syndrome. Open Ophthalmol. J. 9, 149–155 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hamard, P., Hamard, H., Dufaux, J. & Quesnot, S. Optic nerve head blood flow using a laser Doppler velocimeter and haemorheology in primary open-angle glaucoma and normal pressure glaucoma. Br. J. Ophthalmol. 78, 449–453 (1994).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shoji, M. K. et al. Paired optic nerve microvasculature and nailfold capillary measurements in primary open-angle glaucoma. Transl. Vis. Sci. Technol. 10, 13–13 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Anchisi, L., Dessi, S., Pani, A. & Mandas, A. Cholesterol homeostasis: a key to prevent or slow down neurodegeneration. Front. Physiol. 3, 486 (2012).

    CAS 
    PubMed 

    Google Scholar
     

  • Huynh, K. et al. Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease. Nat. Commun. 11, 5698 (2020).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Llano, D. A. & Devanarayan, V., Alzheimer’s Disease Neuroimaging, I. Serum phosphatidylethanolamine and lysophosphatidylethanolamine levels differentiate Alzheimer’s disease from controls and predict progression from mild cognitive impairment. J. Alzheimer’s Dis. 80, 311–319 (2021).

    Article 
    CAS 

    Google Scholar
     

  • Wood, P. L. et al. Targeted lipidomics distinguishes patient subgroups in mild cognitive impairment (MCI) and late-onset Alzheimer’s disease (LOAD). BBA Clin. 5, 25–28 (2016).

    Article 
    PubMed 

    Google Scholar
     

  • Meikle, P. J. et al. Plasma lipid profiling shows similar associations with prediabetes and type 2 diabetes. PLoS One 8, e74341 (2013).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mejia, E. M. & Hatch, G. M. Mitochondrial phospholipids: role in mitochondrial function. J. Bioenerg. Biomembr. 48, 99–112 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Liu, P. et al. The mechanisms of lysophosphatidylcholine in the development of diseases. Life Sci. 247, 117443 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Leruez, S. et al. A plasma metabolomic signature of the exfoliation syndrome involves amino acids, acylcarnitines, and polyamines. Investig. Ophthalmol. Vis. Sci. 59, 1025–1032 (2018).

    Article 
    CAS 

    Google Scholar
     

  • Ho, L. T. Y. et al. Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity. Biochim. Biophys. Acta Mol. Basis Dis. 1866, 165560 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Honjo, M. et al. Autotaxin-lysophosphatidic acid pathway in intraocular pressure regulation and glaucoma subtypes. Investig. Ophthalmol. Vis. Sci. 59, 693–701 (2018).

    Article 
    CAS 

    Google Scholar
     

  • Milbeck, S. M. & Bhattacharya, S. K. Alteration in lysophospholipids and converting enzymes in glaucomatous optic nerves. Investig. Ophthalmol. Vis. Sci. 61, 60 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Edwards, G., Aribindi, K., Guerra, Y., Lee, R. K. & Bhattacharya, S. K. Phospholipid profiles of control and glaucomatous human aqueous humor. Biochimie 101, 232–247 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Aribindi, K., Guerra, Y., Lee, R. K. & Bhattacharya, S. K. Comparative phospholipid profiles of control and glaucomatous human trabecular meshwork. Investig. Ophthalmol. Vis. Sci. 54, 3037–3044 (2013).

    Article 
    CAS 

    Google Scholar
     

  • Aljohani, A. J. et al. Human trabecular meshwork sphingolipid and ceramide profiles and potential latent fungal commensalism. Investig. Ophthalmol. Vis. Sci. 55, 3413–3422 (2014).

    Article 
    CAS 

    Google Scholar
     

  • Aljohani, A. J., Munguba, G. C., Guerra, Y., Lee, R. K. & Bhattacharya, S. K. Sphingolipids and ceramides in human aqueous humor. Mol. Vis. 19, 1966 (2013).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chauhan, M. Z., Valencia, A.-K., Piqueras, M. C., Enriquez-Algeciras, M. & Bhattacharya, S. K. Optic nerve lipidomics reveal impaired glucosylsphingosine lipids pathway in glaucoma. Investig. Ophthalmol. Vis. Sci. 60, 1789–1798 (2019).

    Article 
    CAS 

    Google Scholar
     

  • Kamel, K., Farrell, M. & O’Brien, C. Mitochondrial dysfunction in ocular disease: focus on glaucoma. Mitochondrion 35, 44–53 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Liu, H., Mercieca, K. & Prokosch, V. Mitochondrial markers in aging and primary open-angle glaucoma. J. Glaucoma 29, 295–303 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Kong, G. Y., Van Bergen, N. J., Trounce, I. A. & Crowston, J. G. Mitochondrial dysfunction and glaucoma. J. Glaucoma 18, 93–100 (2009).

    Article 
    PubMed 

    Google Scholar
     

  • Chrysostomou, V., Rezania, F., Trounce, I. A. & Crowston, J. G. Oxidative stress and mitochondrial dysfunction in glaucoma. Curr. Opin. Pharm. 13, 12–15 (2013).

    Article 
    CAS 

    Google Scholar
     

  • Izzotti, A., Bagnis, A. & Sacca, S. C. The role of oxidative stress in glaucoma. Mutat. Res. 612, 105–114 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Benoist d’Azy, C., Pereira, B., Chiambaretta, F. & Dutheil, F. Oxidative and anti-oxidative stress markers in chronic glaucoma: a systematic review and meta-analysis. PLoS One 11, e0166915 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Williams, P. A. et al. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science 355, 756–760 (2017).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gonzalez-Granda, A., Damms-Machado, A., Basrai, M. & Bischoff, S. C. Changes in plasma acylcarnitine and lysophosphatidylcholine levels following a high-fructose diet: a targeted metabolomics study in healthy women. Nutrients 10, 1254 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Calandrella, N., De Seta, C., Scarsella, G. & Risuleo, G. Carnitine reduces the lipoperoxidative damage of the membrane and apoptosis after induction of cell stress in experimental glaucoma. Cell Death Dis. 1, e62 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zarnowski, T. et al. A ketogenic diet may offer neuroprotection in glaucoma and mitochondrial diseases of the optic nerve. Med Hypothesis Discov. Innov. Ophthalmol. 1, 45–49 (2012).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bailey, J. N. et al. Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. Hum. Genet. 133, 1319–1330 (2014).

    Article 
    PubMed 

    Google Scholar
     

  • Hanyuda, A. et al. Low-carbohydrate-diet scores and the risk of primary open-angle glaucoma: data from three US cohorts. Eye 34, 1465–1475 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Khawaja, A. P. et al. Assessing the association of mitochondrial genetic variation with primary open-angle glaucoma using gene-set analyses. Investig. Ophthalmol. Vis. Sci. 57, 5046–5052 (2016).

    Article 
    CAS 

    Google Scholar
     

  • Zeleznik, O. A. et al. Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women. NPJ Breast cancer 7, 1–10 (2021).

    Article 

    Google Scholar
     

  • Zeleznik, O. A. et al. Circulating lysophosphatidylcholines, phosphatidylcholines, ceramides, and sphingomyelins and ovarian cancer risk: a 23-year prospective study. J. Natl Cancer Inst. 112, 628–636 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Zeleznik, O. A. et al. A prospective analysis of circulating plasma metabolites associated with ovarian cancer risk. Cancer Res. 80, 1357–1367 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Townsend, M. K. et al. Reproducibility of metabolomic profiles among men and women in 2 large cohort studies. Clin. Chem. 59, 1657–1667 (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zeleznik, O. A. et al. Intrapersonal stability of plasma metabolomic profiles over 10 years among women. Metabolites 12, 372 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kang, J. H., Loomis, S. J., Rosner, B. A., Wiggs, J. L. & Pasquale, L. R. Comparison of risk factor profiles for primary open-angle glaucoma subtypes defined by pattern of visual field loss: a prospective study. Investig. Ophthalmol. Vis. Sci. 56, 2439–2448 (2015).

    Article 

    Google Scholar
     

  • Kang, J. H., Willett, W. C., Rosner, B. A., Hankinson, S. E. & Pasquale, L. R. Prospective study of alcohol consumption and the risk of primary open-angle glaucoma. Ophthalmic Epidemiol. 14, 141–147 (2007).

    Article 
    PubMed 

    Google Scholar
     

  • Bailey, J. N. et al. Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nat. Genet. 48, 189–194 (2016).

    Article 
    PubMed 

    Google Scholar
     

  • Hysi, P. G. et al. Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. Nat. Genet. 46, 1126–1130 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wiggs, J. L. et al. The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables. J. Glaucoma 22, 517–525 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wiggs, J. L. et al. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA. Hum. Mol. Genet. 20, 4707–4713 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • MacGregor, S. et al. Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma. Nat. Genet. 50, 1067–1071 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Khawaja, A. P. et al. Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nat. Genet. 50, 778–782 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kim, J. et al. Intraocular pressure, glaucoma, and dietary caffeine consumption: a gene-diet interaction study from the UK Biobank. Ophthalmology 128, 866–876 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Kim, J. et al. Statin use in relation to intraocular pressure, glaucoma, and ocular coherence tomography parameters in the UK Biobank. Investig. Ophthalmol. Vis. Sci. 63, 31 (2022).

    Article 
    CAS 

    Google Scholar
     

  • Han, X. et al. Associations of sleep apnoea with glaucoma and age-related macular degeneration: an analysis in the United Kingdom Biobank and the Canadian longitudinal study on aging. BMC Med 19, 104 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Paynter, N.P. et al. Metabolic predictors of incident coronary heart disease in women. Circulation 137, 841–853 (2018)

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • O’Sullivan, J. F. et al. Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes. J. Clin. Invest 127, 4394–4402 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mascanfroni, I. D. et al. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-alpha. Nat. Med. 21, 638–646 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Julkunen, H., Cichonska, A., Slagboom, P. E. & Wurtz, P., Nightingale Health, U.K.B.I. Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population. Elife 10, e63033 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Soininen, P., Kangas, A. J., Wurtz, P., Suna, T. & Ala-Korpela, M. Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics. Circ. Cardiovasc. Genet. 8, 192–206 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mihaleva, V. V. et al. Automated quantum mechanical total line shape fitting model for quantitative NMR-based profiling of human serum metabolites. Anal. Bioanal. Chem. 406, 3091–3102 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kang, J. H. et al. Association of dietary nitrate intake with primary open-angle glaucoma: a prospective analysis from the nurses’ health study and health professionals follow-up study. JAMA Ophthalmol. 134, 294–303 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kang, J. H., Willett, W. C., Rosner, B. A., Hankinson, S. E. & Pasquale, L. R. Caffeine consumption and the risk of primary open-angle glaucoma: a prospective cohort study. Investig. Ophthalmol. Vis. Sci. 49, 1924–1931 (2008).

    Article 

    Google Scholar
     

  • Chiuve, S. E. et al. Alternative dietary indices both strongly predict risk of chronic disease. J. Nutr. 142, 1009–1018 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gao, X., Starmer, J. & Martin, E. R. A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms. Genet Epidemiol. 32, 361–369 (2008).

    Article 
    PubMed 

    Google Scholar
     

  • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. 102, 15545–15550 (2005).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 57, 289–300 (1995).

    MathSciNet 
    MATH 

    Google Scholar
     



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