Sunday, February 25, 2024
BestWooCommerceThemeBuilttoBoostSales-728x90

Precision medicine for psychotic disorders: objective assessment, risk prediction, and pharmacogenomics – Molecular Psychiatry


  • Le-Niculescu H, Niculescu AB. Precision medicine in psychiatry: biomarkers to the forefront. Neuropsychopharmacology. 2022;47:422–3.

    Article 
    PubMed 

    Google Scholar
     

  • Le-Niculescu H, Levey DF, Ayalew M, Palmer L, Gavrin LM, Jain N, et al. Discovery and validation of blood biomarkers for suicidality. Mol Psychiatry. 2013;18:1249–64.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N, et al. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Mol psychiatry. 2015;20:1266–85.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Levey DF, Niculescu EM, Le-Niculescu H, Dainton HL, Phalen PL, Ladd TB, et al. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Mol Psychiatry. 2016;21:768–85.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Niculescu AB, Le-Niculescu H, Levey DF, Phalen PL, Dainton HL, Roseberry K, et al. Precision medicine for suicidality: from universality to subtypes and personalization. Mol Psychiatry. 2017;22:1250–73.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kilka S, Erdmann F, Migdoll A, Fischer G, Weiwad M. The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding. Biochemistry. 2009;48:1900–10.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li SJ, Wang J, Ma L, Lu C, Wang J, Wu JW, et al. Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. Cell Res. 2016;26:336–49.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Parnell E, Culotta L, Forrest MP, Jalloul HA, Eckman BL, Loizzo DD, et al. Excitatory dysfunction drives network and calcium handling deficits in 16p11.2 duplication schizophrenia induced pluripotent stem cell-derived neurons. Biol Psychiatry. 2023;94:153–63.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD, et al. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci USA. 2001;98:4746–51.

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Leirer DJ, Iyegbe CO, Di Forti M, Patel H, Carra E, Fraietta S, et al. Differential gene expression analysis in blood of first episode psychosis patients. Schizophr Res. 2019;209:88–97.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu CM, Fann CS, Chen CY, Liu YL, Oyang YJ, Yang WC, et al. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function. Biol Psychiatry. 2011;70:51–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Forero DA, Herteleer L, De Zutter S, Norrback KF, Nilsson LG, Adolfsson R, et al. A network of synaptic genes associated with schizophrenia and bipolar disorder. Schizophr Res. 2016;172:68–74.

    Article 
    PubMed 

    Google Scholar
     

  • Jaffe AE, Gao Y, Deep-Soboslay A, Tao R, Hyde TM, Weinberger DR, et al. Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex. Nat Neurosci. 2016;19:40–7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, et al. Modelling schizophrenia using human induced pluripotent stem cells. Nature. 2011;473:221–5.

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mozhui K, Wang X, Chen J, Mulligan MK, Li Z, Ingles J, et al. Genetic regulation of Nrxn1 [corrected] expression: an integrative cross-species analysis of schizophrenia candidate genes. Transl Psychiatry. 2011;1:e25.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • McCarthy SE, Gillis J, Kramer M, Lihm J, Yoon S, Berstein Y, et al. De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability. Mol Psychiatry. 2014;19:652–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ozsoy F, Karakus NB, Yigit S, Kulu M. Effect of AUTS2 gene rs6943555 variant in male patients with schizophrenia in a Turkish population. Gene. 2020;756:144913.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Oksenberg N, Ahituv N. The role of AUTS2 in neurodevelopment and human evolution. Trends Genet. 2013;29:600–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pisanu C, Merkouri Papadima E, Melis C, Congiu D, Loizedda A, Orru N et al. Whole genome expression analyses of miRNAs and mRNAs suggest the involvement of miR-320a and miR-155-3p and their targeted genes in lithium response in bipolar disorder. Int J Mol Sci. 2019;20:6040.

  • Schulpen SH, Pennings JL, Piersma AH. Gene expression regulation and pathway analysis after valproic acid and carbamazepine exposure in a human embryonic stem cell-based neurodevelopmental toxicity assay. Toxicol Sci. 2015;146:311–20.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Stroup TS, Gerhard T, Crystal S, Huang C, Olfson M. Comparative effectiveness of clozapine and standard antipsychotic treatment in adults with schizophrenia. Am J Psychiatry. 2016;173:166–73.

    Article 
    PubMed 

    Google Scholar
     

  • Alexander PE, van Kammen DP, Bunney WE Jr. Antipsychotic effects of lithium in schizophrenia. Am J Psychiatry. 1979;136:283–7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zemlan FP, Hirschowitz J, Sautter FJ, Garver DL. Impact of lithium therapy on core psychotic symptoms of schizophrenia. Br J Psychiatry. 1984;144:64–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Moldavsky M, Stein D, Benatov R, Sirota P, Elizur A, Matzner Y, et al. Combined clozapine-lithium treatment for schizophrenia and schizoaffective disorder. Eur Psychiatry. 1998;13:104–6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Puranen A, Koponen M, Lahteenvuo M, Tanskanen A, Tiihonen J, Taipale H. Real-world effectiveness of mood stabilizer use in schizophrenia. Acta Psychiatr Scand. 2023;147:257–66.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lieberman JA, Fenton WS. Delayed detection of psychosis: causes, consequences, and effect on public health. Am J Psychiatry. 2000;157:1727–30.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Miriami E, et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012;148:1293–307.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Niculescu AB, Le-Niculescu H, Levey DF, Roseberry K, Soe KC, Rogers J, et al. Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs. Mol Psychiatry. 2019;24:501–22.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Le-Niculescu H, Roseberry K, Levey DF, Rogers J, Kosary K, Prabha S et al. Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs. Mol Psychiatry. 2020;25:918–38.

  • Niculescu AB, Le-Niculescu H, Roseberry K, Wang S, Hart J, Kaur A et al. Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs. Mol Psychiatry. 2020;25:1651–72.

  • Le-Niculescu H, Roseberry K, Gill SS, Levey DF, Phalen PL, Mullen J, et al. Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Mol Psychiatry. 2021;26:2776–804.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Roseberry K, Le-Niculescu H, Levey DF, Bhagar R, Soe K, Rogers J, et al. Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Mol Psychiatry. 2023;28:2894–912.

  • Le-Niculescu H, Balaraman Y, Patel S, Tan J, Sidhu K, Jerome RE, et al. Towards understanding the schizophrenia code: an expanded convergent functional genomics approach. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:129–58.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Le-Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ, et al. Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol Psychiatry. 2009;14:156–74.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Trubetskoy V, Pardinas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2022;604:502–8.

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jaholkowski P, Hindley GFL, Shadrin AA, Tesfaye M, Bahrami S, Nerhus M et al. Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci. Schizophr Bull. 2023;49:1654–64.

  • Hjelmervik H, Craven AR, Johnsen E, Kompus K, Bless JJ, Sinkeviciute I, et al. Negative valence of hallucinatory voices as predictor of cortical glutamatergic metabolite levels in schizophrenia patients. Brain Behav. 2022;12:e2446.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhao XF, Kohen R, Parent R, Duan Y, Fisher GL, Korn MJ, et al. PlexinA2 forward signaling through Rap1 GTPases regulates dentate gyrus development and schizophrenia-like behaviors. Cell Rep. 2018;22:456–70.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu EQ, Shi L, Birnbaum H, Hudson T, Kessler R. Annual prevalence of diagnosed schizophrenia in the USA: a claims data analysis approach. Psychol Med. 2006;36:1535–40.

    Article 
    PubMed 

    Google Scholar
     

  • He H, Liu Q, Li N, Guo L, Gao F, Bai L, et al. Trends in the incidence and DALYs of schizophrenia at the global, regional and national levels: results from the Global Burden of Disease Study 2017. Epidemiol Psychiatr Sci. 2020;29:e91.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     



  • Source link

    Related Articles

    Leave a Reply

    [td_block_social_counter facebook="beingmedicos1" twitter="being_medicos" youtube="beingmedicosgroup" style="style8 td-social-boxed td-social-font-icons" tdc_css="eyJhbGwiOnsibWFyZ2luLWJvdHRvbSI6IjM4IiwiZGlzcGxheSI6IiJ9LCJwb3J0cmFpdCI6eyJtYXJnaW4tYm90dG9tIjoiMzAiLCJkaXNwbGF5IjoiIn0sInBvcnRyYWl0X21heF93aWR0aCI6MTAxOCwicG9ydHJhaXRfbWluX3dpZHRoIjo3Njh9" custom_title="Stay Connected" block_template_id="td_block_template_8" f_header_font_family="712" f_header_font_transform="uppercase" f_header_font_weight="500" f_header_font_size="17" border_color="#dd3333"]
    - Advertisement -spot_img

    Latest Articles