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RNA N6-methyladenosine (m6A) modification in HNSCC: molecular mechanism and therapeutic potential – Cancer Gene Therapy


  • Hanemaaijer SH, Kok IC, Fehrmann RSN, van der Vegt B, Gietema JA, Plaat BEC, et al. Comparison of carboplatin with 5-fluorouracil vs. cisplatin as concomitant chemoradiotherapy for locally advanced head and neck squamous cell carcinoma. Front Oncol. 2020;10:761.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu D, Pan M, Li Y, Lu T, Wang Z, Liu C, et al. RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner. J Exp Clin Cancer Res. 2022;41:6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Prim. 2020;6:92.

    Article 
    PubMed 

    Google Scholar
     

  • Ye J, Wang Z, Chen X, Jiang X, Dong Z, Hu S, et al. YTHDF1-enhanced iron metabolism depends on TFRC m 6 A methylation. Theranostics 2020;10:12072–89.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gau M, Karabajakian A, Reverdy T, Neidhardt EM, Fayette J. Induction chemotherapy in head and neck cancers: results and controversies. Oral Oncol. 2019;95:164–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang Y, Li L, Ye Z, Zhang L, Yao N, Gai L. Identification of m6A methyltransferase-related genes predicts prognosis and immune infiltrates in head and neck squamous cell carcinoma. Ann Transl Med. 2021;9:1554–1554.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang F, Liao Y, Zhang M, Zhu Y, Wang W, Cai H, et al. N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma. Oncogene 2021;40:3885–98.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang Q, Xu F, Jian A, Yu H, Ye T, Hu W. m6A regulator-mediated methylation modification patterns and tumor microenvironment cell-infiltration characterization in head and neck cancer. Front Cell Dev Biol. 2022;9:803141.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu P. N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway. 2021;12:298.

  • Deng LJ, Deng WQ, Fan SR, Chen MF, Qi M, Lyu WY, et al. m6A modification: recent advances, anticancer targeted drug discovery and beyond. Mol Cancer. 2022;21:52.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Huang GZ, Wu QQ, Zheng ZN, Shao TR, Chen YC, Zeng WS, et al. M6A-related bioinformatics analysis reveals that HNRNPC facilitates progression of OSCC via EMT. Aging 2020;12:11667–84.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ding N, You A, Tian W, Gu L, Deng D. Chidamide increases the sensitivity of non-small cell lung cancer to crizotinib by decreasing c- MET mRNA methylation. Int J Biol Sci. 2020;16:2595–611.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Malacrida A, Rivara M, Di Domizio A, Cislaghi G, Miloso M, Zuliani V, et al. 3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line. Bioorg Medicinal Chem. 2020;28:115300.

    Article 
    CAS 

    Google Scholar
     

  • Deng X, Su R, Weng H, Huang H, Li Z, Chen J. RNA N6-methyladenosine modification in cancers: current status and perspectives. Cell Res. 2018;28:507–17.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lan Q, Liu PY, Bell JL, Wang JY, Hüttelmaier S, Zhang XD, et al. The emerging roles of RNA m6A methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance. Cancer Res. 2021;81:3431–40.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Quan C, Belaydi O, Hu J, Li H, Yu A, Liu P, et al. N6-methyladenosine in cancer immunotherapy: an undervalued therapeutic target. Front Immunol. 2021;12:697026.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang T, Kong S, Tao M, Ju S. The potential role of RNA N6-methyladenosine in cancer progression. Mol Cancer. 2020;19:88.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pai S, Yadav VK, Kuo KT, Pikatan NW, Lin CS, Chien MH, et al. PDK1 inhibitor BX795 improves cisplatin and radio-efficacy in oral squamous cell carcinoma by downregulating the PDK1/CD47/Akt-mediated glycolysis signaling pathway. IJMS 2021;22:11492.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zeng C, Huang W, Li Y, Weng H. Roles of METTL3 in cancer: mechanisms and therapeutic targeting. J Hematol Oncol. 2020;13:117. Dec

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen X, Liu Y, Sun D, Sun R, Wang X, Li M, et al. Long noncoding RNA lnc‐H2AFV‐1 promotes cell growth by regulating aberrant m6A RNA modification in head and neck squamous cell carcinoma. Cancer Sci. 2022;113:2071–84.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ai Y, Liu S, Luo H, Wu S, Wei H, Tang Z, et al. METTL3 intensifies the progress of oral squamous cell carcinoma via modulating the m6A amount of PRMT5 and PD-L1. J Immunol Res. 2021;2021:1–15.


    Google Scholar
     

  • Wang X, Tian L, Li Y, Wang J, Yan B, Yang L, et al. RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent. J Exp Clin Cancer Res. 2021;40:80.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li Y, Yan B, Wang X, Li Q, Kan X, Wang J, et al. ALKBH5‐mediated m6A modification of lncRNA KCNQ1OT1 triggers the development of LSCC via upregulation of HOXA9. J Cell Mol Med. 2022;26:385–98.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jin S, Li M, Chang H, Wang R, Zhang Z, Zhang J, et al. The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma. Mol Cancer. 2022;21:97.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Du M, Peng Y, Li Y, Sun W, Zhu H, Wu J, et al. MYC-activated RNA N6-methyladenosine reader IGF2BP3 promotes cell proliferation and metastasis in nasopharyngeal carcinoma. Cell Death Discov. 2022;8:53.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Peng J, Zheng H, Liu F, Wu Q, Liu S. The m6A methyltransferase METTL3 affects autophagy and progression of nasopharyngeal carcinoma by regulating the stability of lncRNA ZFAS1. Infect Agent Cancer 2022;17:1.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang Z, Ming X, Huang S, Yang M, Zhou X, Fang J. Comprehensive analysis of m6A regulators characterized by the immune cell infiltration in head and neck squamous cell carcinoma to aid immunotherapy and chemotherapy. Front Oncol. 2021;11:764798.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xiang M, Liu W, Tian W, You A, Deng D. RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy. Epigenomics 2020;12:801–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jing FY, Zhou LM, Ning YJ, Wang XJ, Zhu YM. The biological function, mechanism, and clinical significance of m6A RNA modifications in head and neck carcinoma: a systematic review. Front Cell Dev Biol. 2021;9:683254.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang F, Jin H, Que B, Chao Y, Zhang H, Ying X, et al. Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis. Oncogene 2019;38:4755–72.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li S, Wu Q, Liu J, Zhong Y. Identification of Two m6A readers YTHDF1 and IGF2BP2 as immune biomarkers in head and neck squamous cell carcinoma. Front Genet. 2022;13:903634.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen Y, Jiang X, Li X, Yan D, Liu J, Yang J, et al. The methylation modification of m6A regulators contributes to the prognosis of head and neck squamous cell carcinoma. Ann Transl Med. 2021;9:1346–1346.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fang Z, Zhao J, Xie W, Sun Q, Wang H, Qiao B. LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by sunppressing miR-184 expression. Cancer Med. 2017;6:2897–908.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen J, Lu T, Zhong F, Lv Q, Fang M, Tu Z, et al. A signature of N6-methyladenosine regulator-related genes predicts prognoses and immune responses for head and neck squamous cell carcinoma. Front Immunol. 2022;13:809872.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lin H, Wang Y, Wang P, Long F, Wang T. Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance. Mol Cancer. 2022;21:148.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guan S, Wei J, Huang L, Wu L. Chemotherapy and chemo-resistance in nasopharyngeal carcinoma. Eur J Med Chem. 2020;207:112758.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mehanna H, Robinson M, Hartley A, Kong A, Foran B, Fulton-Lieuw T, et al. Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial. Lancet. 2019;393:51–60.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • EGöttgens EL, Ostheimer C, Bussink J, Span PN, Hammod EM. HPV, hypoxia and radiation response in head and neck cancer. Br J Radiol. 2018;92:20180047.

  • Zhou S, Bai ZL, Xia D, Zhao ZJ, Zhao R, Wang YY, et al. FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation. Mol Carcinog. 2018;57:590–7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, et al. Radioresistance in head and neck squamous cell carcinoma: biological bases and therapeutic implications: radioresistance in HNSCC. Head Neck. 2015;37:763–70.

    Article 
    PubMed 

    Google Scholar
     

  • Liu L, Wu Y, Li Q, Liang J, He Q, Zhao L, et al. METTL3 promotes tumorigenesis and metastasis through BMI1 m6A methylation in oral squamous cell carcinoma. Mol Ther. 2020;28:2177–90.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     



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