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Small fibre pathology, small fibre symptoms and pain in fibromyalgia syndrome – Scientific Reports


  • Häuser, W. et al. Modified 2016 American College of Rheumatology fibromyalgia criteria, the analgesic, anesthetic, and addiction clinical trial translations innovations opportunities and networks-American Pain Society Pain Taxonomy, and the prevalence of fibromyalgia. Arthritis Care Res. (Hoboken) 73(5), 617–625 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Nicholas, M. et al. The IASP classification of chronic pain for ICD-11: Chronic primary pain. Pain 160(1), 28–37 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Lichtenstein, A., Tiosano, S. & Amital, H. The complexities of fibromyalgia and its comorbidities. Curr. Opin. Rheumatol. 30(1), 94–100 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Vecchio, E. et al. Peripheral and central nervous system correlates in fibromyalgia. Eur. J. Pain 24(8), 1537–1547 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nijs, J. et al. Central sensitisation in chronic pain conditions: Latest discoveries and their potential for precision medicine. Lancet Rheumatol. 3(5), e383–e392 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • O’Brien, A. T. et al. Defective endogenous pain modulation in fibromyalgia: A meta-analysis of temporal summation and conditioned pain modulation paradigms. J. Pain 19(8), 819–836 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Uceyler, N. et al. Small fibre pathology in patients with fibromyalgia syndrome. Brain 136(Pt 6), 1857–1867 (2013).

    Article 
    PubMed 

    Google Scholar
     

  • Evdokimov, D. et al. Reduction of skin innervation is associated with a severe fibromyalgia phenotype. Ann. Neurol. 86(4), 504–516 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Grayston, R. et al. A systematic review and meta-analysis of the prevalence of small fiber pathology in fibromyalgia: Implications for a new paradigm in fibromyalgia etiopathogenesis. Semin. Arthritis Rheum. 48(5), 933–940 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Serra, J. et al. Hyperexcitable C nociceptors in fibromyalgia. Ann. Neurol. 75(2), 196–208 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tavakoli, M. et al. Corneal confocal microscopy: A novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Diabetes Care 33(8), 1792–1797 (2010).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Petropoulos, I. N. et al. Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy. Diabetes Care 36(11), 3646–3651 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Klitsch, A. et al. Reduced association between dendritic cells and corneal sub-basal nerve fibers in patients with fibromyalgia syndrome. J. Peripher. Nerv. Syst. 25(1), 9–18 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Petropoulos, I. N. et al. Corneal confocal microscopy to image small nerve fiber degeneration: Ophthalmology meets neurology. Front. Pain Res. 2, 725363 (2021).

    Article 

    Google Scholar
     

  • Petropoulos, I. N. et al. Corneal confocal microscopy to image small nerve fiber degeneration: Ophthalmology meets neurology. Front. Pain Res. 2(47), 363 (2021).


    Google Scholar
     

  • Moulton, E. A. & Borsook, D. C-fiber assays in the cornea vs skin. Brain Sci. 9(11), 320 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ramírez, M. et al. Small fiber neuropathy in women with fibromyalgia. An in vivo assessment using corneal confocal bio-microscopy. Semin. Arthritis Rheum. 45(2), 214–219 (2015).

    Article 
    PubMed 

    Google Scholar
     

  • Oudejans, L. et al. Cornea nerve fiber quantification and construction of phenotypes in patients with fibromyalgia. Sci. Rep. 6, 23573 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kösehasanoğullari, M., Erdinç Gündüz, N. & Akalin, E. Is fibromyalgia syndrome a neuropathic pain syndrome? Arch. Rheumatol. 34(2), 196–203 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cheng, C. W. et al. Fibromyalgia: Is it a neuropathic pain? Pain Manag. 8(5), 377–388 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Petropoulos, I. N. et al. Rapid automated diagnosis of diabetic peripheral neuropathy with in vivo corneal confocal microscopy. Investig. Ophthalmol. Vis. Sci. 55(4), 2071–2078 (2014).

    Article 

    Google Scholar
     

  • Federation, I.D. Resources|IDF Diabetes Atlas 2021.

  • Rolke, R. et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values. Pain 123(3), 231–243 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Fasolino, A. et al. Small-fibre pathology has no impact on somatosensory system function in patients with fibromyalgia. Pain 161(10), 2385 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lodahl, M., Treister, R. & Oaklander, A. L. Specific symptoms may discriminate between fibromyalgia patients with vs without objective test evidence of small-fiber polyneuropathy. Pain Rep. 3(1), e633 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Leone, C. et al. Small-fibre damage is associated with distinct sensory phenotypes in patients with fibromyalgia and small-fibre neuropathy. Eur. J. Pain 27(1), 163–173 (2023).

    Article 
    PubMed 

    Google Scholar
     

  • Sandkühler, J. Models and mechanisms of hyperalgesia and allodynia. Physiol. Rev. 89(2), 707–758 (2009).

    Article 
    PubMed 

    Google Scholar
     

  • Treede, R. D. et al. Peripheral and central mechanisms of cutaneous hyperalgesia. Prog. Neurobiol. 38(4), 397–421 (1992).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • van de Donk, T. et al. Cornea nerve fibre state determines analgesic response to tapentadol in fibromyalgia patients without effective endogenous pain modulation. Eur. J. Pain 23(9), 1586–1595 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Staud, R., Godfrey, M. M. & Stroman, P. W. Fibromyalgia is associated with hypersensitivity but not with abnormal pain modulation: evidence from QST trials and spinal fMRI. Front. Pain Res. 4, 1284103 (2023).

    Article 

    Google Scholar
     

  • Staud, R. et al. Efficiency of pain inhibition and facilitation of fibromyalgia patients is not different from healthy controls: Relevance of sensitivity-adjusted test stimuli. Br. J. Pain 17(2), 182–194 (2023).

    Article 
    PubMed 

    Google Scholar
     

  • Marshall, A. et al. Spinal disinhibition: Evidence for a hyperpathia phenotype in painful diabetic neuropathy. Brain Commun. 5(2), 051 (2023).

    Article 

    Google Scholar
     

  • Ramírez, M. et al. Correlation between corneal nerve density and symptoms of small fiber neuropathy in patients with fibromyalgia: The confounding role of severe anxiety or depression. J. Clin. Rheumatol. 27, e606 (2020).

    Article 

    Google Scholar
     

  • Goebel, A. et al. Passive transfer of fibromyalgia symptoms from patients to mice. J. Clin. Investig. 131, 13 (2021).

    Article 

    Google Scholar
     

  • Krock, E. et al. Fibromyalgia patients with elevated levels of anti-satellite glia cell immunoglobulin G antibodies present with more severe symptoms. Pain 164(8), 1828–1840 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Harte, S. E. et al. Reduced intraepidermal nerve fiber density after a sustained increase in insular glutamate: A proof-of-concept study examining the pathogenesis of small fiber pathology in fibromyalgia. Pain Rep. 2(3), e590 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kuchinad, A. et al. Accelerated brain gray matter loss in fibromyalgia patients: Premature aging of the brain? J. Neurosci. 27(15), 4004–4007 (2007).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Čeko, M. et al. Default mode network changes in fibromyalgia patients are largely dependent on current clinical pain. Neuroimage 216, 116877 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Aster, H. C. et al. CNS imaging characteristics in fibromyalgia patients with and without peripheral nerve involvement. Sci. Rep. 12(1), 6707 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Terkelsen, A. J. et al. The diagnostic challenge of small fibre neuropathy: Clinical presentations, evaluations, and causes. Lancet Neurol. 16(11), 934–944 (2017).

    Article 
    PubMed 

    Google Scholar
     

  • Goebel, A. et al. Research recommendations following the discovery of pain sensitizing IgG autoantibodies in fibromyalgia syndrome. Pain Med. 23(6), 1084–1094 (2021).

    Article 
    PubMed Central 

    Google Scholar
     

  • Wolfe, F. et al. 2016 revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin. Arthritis Rheum. 46(3), 319–329 (2016).

    Article 
    PubMed 

    Google Scholar
     

  • Bennett, R. M. et al. Minimal clinically important difference in the fibromyalgia impact questionnaire. J. Rheumatol. 36(6), 1304–1311 (2009).

    Article 
    PubMed 

    Google Scholar
     

  • Dyck, P. J. et al. Neuropathy symptom profile in health, motor neuron disease, diabetic neuropathy, and amyloidosis. Neurology 36(10), 1300–1308 (1986).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hoitsma, E., De Vries, J. & Drent, M. The small fiber neuropathy screening list: Construction and cross-validation in sarcoidosis. Respir. Med. 105(1), 95–100 (2011).

    Article 
    PubMed 

    Google Scholar
     

  • Freynhagen, R. et al. painDETECT: A new screening questionnaire to identify neuropathic components in patients with back pain. Curr. Med. Res. Opin. 22(10), 1911–1920 (2006).

    Article 
    PubMed 

    Google Scholar
     

  • Melzack, R. The McGill Pain Questionnaire: Major properties and scoring methods. Pain 1(3), 277–299 (1975).

    Article 
    PubMed 

    Google Scholar
     

  • Tavakoli, M. & Malik, R. A. Corneal confocal microscopy: A novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies. J. Vis. Exp. 47, 2194 (2011).


    Google Scholar
     

  • Chen, X. et al. Small nerve fiber quantification in the diagnosis of diabetic sensorimotor polyneuropathy: Comparing corneal confocal microscopy with intraepidermal nerve fiber density. Diabetes Care 38(6), 1138–1144 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Perkins, B. A. et al. Corneal confocal microscopy for identification of diabetic sensorimotor polyneuropathy: A Pooled Multinational Consortium Study. Diabetologia 61(8), 1856–1861 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Geber, C. et al. Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): A multi-centre study. Pain 152(3), 548–556 (2011).

    Article 
    PubMed 

    Google Scholar
     



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