Sunday, February 25, 2024
BestWooCommerceThemeBuilttoBoostSales-728x90

The effects of OPRM1 118A>G on methadone response in pain management in advanced cancer at end of life – Scientific Reports


  • Wiffen, P. J., Wee, B., Derry, S., Bell, R. F. & Moore, R. A. Opioids for cancer pain—An overview of Cochrane reviews. Cochrane Database Syst. Rev. 7, CD012592. https://doi.org/10.1002/14651858.CD012592.pub2 (2017).

    Article 
    PubMed 

    Google Scholar
     

  • Nicholson, A. B., Watson, G. R., Derry, S. & Wiffen, P. J. Methadone for cancer pain. Cochrane Database Syst. Rev. 2, CD003971 (2017).

    PubMed 

    Google Scholar
     

  • World Health Organization. WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents Vol. 138 (World Health Organization, 2018).


    Google Scholar
     

  • Patel, J. N., Wiebe, L. A., Dunnenberger, H. M. & McLeod, H. L. Value of supportive care pharmacogenomics in oncology practice. Oncologist 23, 956–964. https://doi.org/10.1634/theoncologist.2017-0599 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Matic, M., de Wildt, S. N., Tibboel, D. & van Schaik, R. H. N. Analgesia and opioids: A pharmacogenetics shortlist for implementation in clinical practice. Clin. Chem. 63, 1204–1213. https://doi.org/10.1373/clinchem.2016.264986 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mura, E. et al. Consequences of the 118A>G polymorphism in the OPRM1 gene: Translation from bench to bedside?. J. Pain Res. 6, 331–353. https://doi.org/10.2147/JPR.S42040 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kumar, S., Kundra, P., Ramsamy, K. & Surendiran, A. Pharmacogenetics of opioids: A narrative review. Anaesthesia 74, 1456–1470. https://doi.org/10.1111/anae.14813 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bugada, D., Lorini, L. F., Fumagalli, R. & Allegri, M. Genetics and opioids: Towards more appropriate prescription in cancer pain. Cancers (Basel) 12, 2020. https://doi.org/10.3390/cancers12071951 (1951).

    Article 
    CAS 

    Google Scholar
     

  • Wang, X. S. et al. Association of single nucleotide polymorphisms of ABCB1, OPRM1 and COMT with pain perception in cancer patients. J. Huazhong Univ. Sci. Technol. Med. Sci. 35, 752–758. https://doi.org/10.1007/s11596-015-1502-6 (2015).

    Article 
    CAS 

    Google Scholar
     

  • Hajj, A. et al. OPRM1 c.118A>G polymorphism and duration of morphine treatment associated with morphine doses and quality-of-life in palliative cancer pain settings. Int. J. Mol. Sci. 18, 669. https://doi.org/10.3390/ijms18040669 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Klepstad, P. et al. The 118 A>G polymorphism in the human µ-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiologica Scandinavica 48, 1232–1239. https://doi.org/10.1111/j.1399-6576.2004.00517.x (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Campa, D., Gioia, A., Tomei, A., Poli, P. & Barale, R. Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Clin. Pharmacol. Ther. 83, 559–566. https://doi.org/10.1038/sj.clpt.6100385 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gong, X. D. et al. Gene polymorphisms of OPRM1 A118G and ABCB1 C3435T may influence opioid requirements in Chinese patients with cancer pain. Asian Pac. J. Cancer Prev. 14, 2937–2943. https://doi.org/10.7314/apjcp.2013.14.5.2937 (2013).

    Article 
    PubMed 

    Google Scholar
     

  • Li, Q., Liu, Y., Yu, Y. & Wang, Y. Association of analgesic effects of oxycodone hydrochloride with the A118G of OPRM1 genes in patients with cancer pain. Her. Med. 35, 481–484. https://doi.org/10.3870/j.issn.1004-0781.2016.05.0 (2016).

    Article 
    CAS 

    Google Scholar
     

  • Ying, L., Feixue, W., Sun, L., Xiang, L. & Wang, Y. Effects of OPRM1 A118G gene polymorphism on the dosage of opioids in Chinese Han population patients with cancer pain. China Pharm. 27, 2737–2739 (2016).


    Google Scholar
     

  • Chatti, I. et al. Association of the OPRM1 and COMT genes’ polymorphisms with the efficacy of morphine in Tunisian cancer patients: Impact of the high genetic heterogeneity in Tunisia?. Therapie 71, 507–513. https://doi.org/10.1016/j.therap.2016.04.004 (2016).

    Article 
    PubMed 

    Google Scholar
     

  • Droney, J. M. et al. Analgesia and central side-effects: Two separate dimensions of morphine response. Br. J. Clin. Pharmacol. 75, 1340–1350. https://doi.org/10.1111/bcp.12008 (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Klepstad, P. et al. Influence from genetic variability on opioid use for cancer pain: A European genetic association study of 2294 cancer pain patients. Pain 152, 1139–1145. https://doi.org/10.1016/j.pain.2011.01.040 (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Matsuoka, H. et al. Expression changes in arrestin beta 1 and genetic variation in catechol-O-methyltransferase are biomarkers for the response to morphine treatment in cancer patients. Oncol. Rep. 27, 1393–1399. https://doi.org/10.3892/or.2012.1660 (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Naito, T. et al. CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone. J. Clin. Pharmacol. 51, 1529–1538. https://doi.org/10.1177/0091270010388033 (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Oosten, A. W. et al. Opioid treatment failure in cancer patients: The role of clinical and genetic factors. Pharmacogenomics 17, 1391–1403. https://doi.org/10.2217/pgs-2016-0082 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ross, J. R. et al. Clinical response to morphine in cancer patients and genetic variation in candidate genes. Pharmacogenom. J. 5, 324–336. https://doi.org/10.1038/sj.tpj.6500327 (2005).

    Article 
    CAS 

    Google Scholar
     

  • Takemura, M. et al. Comparison of the effects of OPRM1 A118G polymorphism using different opioids: A prospective study. J. Pain Symptom Manage. 67, 39–49. https://doi.org/10.1016/j.jpainsymman.2023.09.017 (2023).

  • Mercadante, S. & Bruera, E. Methadone as a first-line opioid in cancer pain management: A systematic review. J. Pain Symptom Manage 55, 998–1003. https://doi.org/10.1016/j.jpainsymman.2017.10.017 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Good, P. et al. Therapeutic challenges in cancer pain management: A systematic review of methadone. J. Pain Palliat. Care Pharmacother. 28, 197–205. https://doi.org/10.3109/15360288.2014.938883 (2014).

    Article 
    PubMed 

    Google Scholar
     

  • Levran, O. & Kreek, M. J. Population-specific genetic background for the OPRM1 variant rs1799971 (118A>G): Implications for genomic medicine and functional analysis. Mol. Psychiatry 26, 3169–3177. https://doi.org/10.1038/s41380-020-00902-4 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • National Library of Medicine. National Center for Biotechnology. Single Nucleotide Polymorphism Database. Reference SNP report rs1799971. https://www.ncbi.nlm.nih.gov/snp/rs1799971 (2023).

  • Matic, M. et al. Advanced cancer pain: The search for genetic factors correlated with interindividual variability in opioid requirement. Pharmacogenomics 18, 1133–1142. https://doi.org/10.2217/pgs-2017-0060 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gray, K., Adhikary, S. D. & Janicki, P. Pharmacogenomics of analgesics in anesthesia practice: A current update of literature. J. Anaesthesiol. Clin. Pharmacol. 34, 155–160. https://doi.org/10.4103/joacp.JOACP_319_17 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nielsen, L. M. et al. Association between human pain-related genotypes and variability in opioid analgesia: An updated review. Pain Pract. 15, 580–594. https://doi.org/10.1111/papr.12232 (2015).

    Article 
    PubMed 

    Google Scholar
     

  • Ren, Z. Y. et al. The impact of genetic variation on sensitivity to opioid analgesics in patients with postoperative pain: A systematic review and meta-analysis. Pain Physician 18, 131–152 (2015).

    PubMed 

    Google Scholar
     

  • Zhang, X. et al. The relevance of the OPRM1 118A>G genetic variant for opioid requirement in pain treatment: A meta-analysis. Pain Physician 22, 331–340 (2019).

    PubMed 

    Google Scholar
     

  • Aroke, E. N. & Kittelsrud, J. M. A primer to pharmacogenetics of postoperative pain management. AANA J. 87, 131–137 (2019).

    PubMed 

    Google Scholar
     

  • Gabriel, R. A., Burton, B. N., Urman, R. D. & Waterman, R. S. Genomics testing and personalized medicine in the preoperative setting. Anesthesiol. Clin. 36, 639–652. https://doi.org/10.1016/j.anclin.2018.07.014 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Knezevic, N. N., Tverdohleb, T., Knezevic, I. & Candido, K. D. The role of genetic polymorphisms in chronic pain patients. Int. J. Mol. Sci. 19, 1707. https://doi.org/10.3390/ijms19061707 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yamamoto, P. A., Conchon Costa, A. C., Lauretti, G. R. & de Moraes, N. V. Pharmacogenomics in chronic pain therapy: From disease to treatment and challenges for clinical practice. Pharmacogenomics 20, 971–982. https://doi.org/10.2217/pgs-2019-0066 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yu, Z., Wen, L., Shen, X. & Zhang, H. Effects of the OPRM1 A118G Polymorphism (rs1799971) on opioid analgesia in cancer pain: A systematic review and meta-analysis. Clin. J. Pain 35, 77–86. https://doi.org/10.1097/AJP.0000000000000636 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Liu, Y. C. & Wang, W. S. Human mu-opioid receptor gene A118G polymorphism predicts the efficacy of tramadol/acetaminophen combination tablets (Ultracet) in oxaliplatin-induced painful neuropathy. Cancer 118, 1718–1725. https://doi.org/10.1002/cncr.26430 (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Fonseca, F. & Torrens, M. Pharmacogenetics of methadone response. Mol. Diagn. Ther. 22, 57–78. https://doi.org/10.1007/s40291-017-0311-y (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Taqi, M. M., Faisal, M. & Zaman, H. OPRM1 A118G polymorphisms and its role in opioid addiction: Implication on severity and treatment approaches. Pharmgenom. Pers. Med. 12, 361–368. https://doi.org/10.2147/PGPM.S198654 (2019).

    Article 
    CAS 

    Google Scholar
     

  • Oueslati, B., Moula, O. & Ghachem, R. The impact of OPRM1’s genetic polymorphisms on methadone maintenance treatment in opioid addicts: A systematic review. Pharmacogenomics 19, 741–747. https://doi.org/10.2217/pgs-2018-0017 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yennurajalingam, S. et al. Genetic factors associated with pain severity, daily opioid dose requirement, and pain response among advanced cancer patients receiving supportive care. J. Pain Symptom Manage 62, 785–795. https://doi.org/10.1016/j.jpainsymman.2021.03.024 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Vieira, C. M. P., Fragoso, R. M., Pereira, D. & Medeiros, R. Pain polymorphisms and opioids: An evidence based review. Mol. Med. Rep. 19, 1423–1434. https://doi.org/10.3892/mmr.2018.9792 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Clinical Pharmacogenetics Implementation Consortium. CPIC guidelines. https://cpicpgx.org/guidelines/. (2023).

  • Kosciuczuk, U., Knapp, P. & Lotowska-Cwiklewska, A. M. Opioid-induced immunosuppression and carcinogenesis promotion theories create the newest trend in acute and chronic pain pharmacotherapy. Clinics (Sao Paulo). 75, e1554. https://doi.org/10.6061/clinics/2020/e1554 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • De Gregori, M., Diatchenko, L., Belfer, I. & Allegri, M. OPRM1 receptor as new biomarker to help the prediction of post mastectomy pain and recurrence in breast cancer. Minerva Anestesiol. 81, 894–900 (2015).

    PubMed 

    Google Scholar
     

  • George, R. et al. Can saliva and plasma methadone concentrations be used for enantioselective pharmacokinetic and pharmacodynamic studies in patients with advanced cancer?. Clin. Ther. 39, 1840–1848. https://doi.org/10.1016/j.clinthera.2017.07.044 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Cleeland, C. S. & Ryan, K. M. Pain assessment: global use of the Brief Pain Inventory. Ann. Acad. Med. Singap. 23, 129–138 (1994).

    CAS 
    PubMed 

    Google Scholar
     

  • Chacon-Cortes, D., Haupt, L. M., Lea, R. A. & Griffiths, L. R. Comparison of genomic DNA extraction techniques from whole blood samples: A time, cost and quality evaluation study. Mol. Biol. Rep. 39, 5961–5966. https://doi.org/10.1007/s11033-011-1408-8 (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar
     



  • Source link

    Related Articles

    Leave a Reply

    [td_block_social_counter facebook="beingmedicos1" twitter="being_medicos" youtube="beingmedicosgroup" style="style8 td-social-boxed td-social-font-icons" tdc_css="eyJhbGwiOnsibWFyZ2luLWJvdHRvbSI6IjM4IiwiZGlzcGxheSI6IiJ9LCJwb3J0cmFpdCI6eyJtYXJnaW4tYm90dG9tIjoiMzAiLCJkaXNwbGF5IjoiIn0sInBvcnRyYWl0X21heF93aWR0aCI6MTAxOCwicG9ydHJhaXRfbWluX3dpZHRoIjo3Njh9" custom_title="Stay Connected" block_template_id="td_block_template_8" f_header_font_family="712" f_header_font_transform="uppercase" f_header_font_weight="500" f_header_font_size="17" border_color="#dd3333"]
    - Advertisement -spot_img

    Latest Articles