A first-of-its-kind non-hormonal drug to treat hot flushes has been approved in the US. Targeting connections in the brain that change during menopause, the drug, called fezolinetant, could provide relief for those who aren’t able to take hormonal replacement therapy. Madeleine Finlay speaks to endocrinologist and menopause specialist Prof Annice Mukherjee to find out what we know about the mechanism that causes hot flushes, how this new drug works, and what it might mean for those experiencing menopause in the future.